Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | EDNRB | P24530 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14745239 | 0.92 | PDE3B (0.43) | RXFP1PDE3BPDE3A | |
| SCHEMBL14745819 | 0.85 | GSK3B (0.43) | SMN1; SMN2KDM4EALDH1A1GAARXFP1 | |
| SCHEMBL14745816 | 0.81 | PDE3B (0.43) | ALDH1A1RXFP1PDE3BPDE3AMAPT | |
| SCHEMBL14745499 | 0.81 | PDE3B (0.43) | RXFP1PDE3BPDE3ATP53 | |
| SCHEMBL14741167 | 0.78 | KDM4E (0.57) | SMN1; SMN2KDM4EALDH1A1GAARXFP1 | |
| SCHEMBL14741114 | 0.75 | SERPINE1 (0.42) | KDM4EGAAPDE3BPDE3AMAPT | |
| SCHEMBL14745238 | 0.75 | SERPINE1 (0.42) | KDM4EGAAPDE3BPDE3A | |
| SCHEMBL14745764 | 0.74 | SERPINE1 (0.31) | — | |
| SCHEMBL14741120 | 0.73 | KDM4E (0.45) | SMN1; SMN2KDM4EALDH1A1GAARXFP1 | |
| SCHEMBL14745775 | 0.71 | CDC7 (0.31) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2750505-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC Therapeutics, Inc. (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013033240-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC THERAPEUTICS, INC. (US) | 2013-03-07 | — | — | WO | disclosed |