Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14757974 | 0.88 | MAPT (0.39) | MAPTLMNAPIK3CDADORA2AJAK2 | |
| SCHEMBL14746234 | 0.82 | EPHB3 (0.41) | MAPTADORA2AJAK2ALDH1A1ADORA1 | |
| SCHEMBL14757898 | 0.79 | MAPT (0.40) | MAPTPIK3CDPIK3R1JAK2ALDH1A1 | |
| SCHEMBL14745931 | 0.74 | TDP2 (0.37) | LMNAADORA2AJAK2JAK1ALDH1A1 | |
| SCHEMBL14758034 | 0.68 | FABP4 (0.36) | MAPTLMNASMN1; SMN2JAK2ALDH1A1 | |
| SCHEMBL14757896 | 0.68 | JAK2 (0.36) | PIK3CDJAK2ALDH1A1 | |
| SCHEMBL14758362 | 0.68 | KDM4E (0.36) | PIK3CDJAK2JAK1ALDH1A1TSHR | |
| SCHEMBL14741484 | 0.68 | PARP1 (0.45) | JAK2JAK1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL19226350 | 0.67 | JAK2 (0.53) | LMNAJAK2JAK1ALDH1A1GAA | |
| SCHEMBL14757957 | 0.67 | TGFBR1 (0.39) | JAK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013033093-A1 | HETEROCYCLIC COMPOUNDS AS JANUS KINASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2013-03-07 | — | — | WO | disclosed |