Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 3/20 | 0.37 |
| ▸ | EPHB3 | P54753 | 4/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | BTK | Q06187 | 3/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14757972 | 0.84 | TGFBR1 (0.39) | TDP2KDM4EALDH1A1JAK3BTK | |
| SCHEMBL12066293 | 0.75 | TGFBR1 (0.42) | ADORA3KDM4EALDH1A1HTTJAK3 | |
| SCHEMBL14745860 | 0.74 | MAPT (0.38) | ADORA2AALDH1A1ADORA1LMNAJAK2 | |
| SCHEMBL19226350 | 0.74 | JAK2 (0.53) | KDM4EALDH1A1JAK3LMNAJAK2 | |
| SCHEMBL12395227 | 0.72 | NUDT1 (0.47) | ADORA2AJAK3ADORA1JAK2JAK1 | |
| SCHEMBL20839881 | 0.70 | TDP2 (0.56) | TDP2EPHB3HTTJAK3LMNA | |
| SCHEMBL12395226 | 0.68 | TGFBR1 (0.34) | ADORA3ADORA2AADORA1 | |
| SCHEMBL21439130 | 0.67 | SPR (0.44) | EPHB3ADORA2AALDH1A1SPRADORA1 | |
| SCHEMBL13676572 | 0.66 | AURKA (0.39) | JAK3JAK2TTK | |
| SCHEMBL12345323 | 0.66 | AURKA (0.39) | JAK3JAK2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013033093-A1 | HETEROCYCLIC COMPOUNDS AS JANUS KINASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2013-03-07 | — | — | WO | disclosed |