Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | EDNRB | P24530 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14746157 | 0.91 | MRGPRX4 (0.35) | MRGPRX4KEAP1NFE2L2MAPTALDH1A1 | |
| SCHEMBL14745700 | 0.85 | ALDH1A1 (0.34) | MAPTALDH1A1L3MBTL1DCTPP1KDM4E | |
| SCHEMBL14746158 | 0.85 | MAPT (0.34) | MRGPRX4MAPTALDH1A1L3MBTL1RORC | |
| SCHEMBL14745459 | 0.81 | ABCB1 (0.41) | MAPTALDH1A1USP2ABCB1KDM4E | |
| SCHEMBL14745012 | 0.80 | ABCB1 (0.41) | KEAP1NFE2L2MAPTALDH1A1L3MBTL1 | |
| SCHEMBL14741313 | 0.80 | GRK6 (0.41) | MAPTALDH1A1L3MBTL1PARP1KMT2A | |
| SCHEMBL14745359 | 0.80 | PSMD14 (0.38) | MRGPRX4MAPTALDH1A1L3MBTL1USP2 | |
| SCHEMBL14745409 | 0.79 | GFER (0.39) | MRGPRX4MAPTALDH1A1L3MBTL1USP2 | |
| SCHEMBL14745493 | 0.79 | ALDH1A1 (0.39) | MAPTALDH1A1L3MBTL1USP2KDM4E | |
| SCHEMBL14745618 | 0.79 | ALDH1A1 (0.42) | MRGPRX4KEAP1NFE2L2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2750505-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC Therapeutics, Inc. (US) | 2014-07-09 | — | — | EP | claimed |
| WO-2013033240-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC THERAPEUTICS, INC. (US) | 2013-03-07 | — | — | WO | claimed |