Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CES1 | P23141 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14479703 | 1.00 | ATM (0.46) | ATMHTTGAACYP2C19DRD4 | |
| SCHEMBL28289534 | 1.00 | ATM (0.46) | ATMHTTGAACYP2C19DRD4 | |
| SCHEMBL2470468 | 0.78 | ATM (0.48) | ATMHTTGAACYP2C19DRD4 | |
| SCHEMBL14626837 | 0.77 | CES2 (0.39) | DRD4CA1CA2CES1KDM4E | |
| SCHEMBL14420559 | 0.77 | GAA (0.47) | ATMHTTGAAHPGDMEN1 | |
| SCHEMBL3891431 | 0.76 | GSK3B (0.48) | ATMHTTGAACYP2C19DRD4 | |
| SCHEMBL7331705 | 0.76 | ATM (0.46) | ATMHTTGAACYP2C19DRD4 | |
| SCHEMBL6161952 | 0.76 | GSK3B (0.48) | ATMHTTGAACYP2C19DRD4 | |
| SCHEMBL22024926 | 0.76 | GSK3B (0.48) | ATMHTTGAACYP2C19DRD4 | |
| SCHEMBL9834835 | 0.76 | ATM (0.46) | ATMHTTGAACYP2C19DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389567-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2013-03-05 | — | — | US | disclosed |