Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22024926 | 1.00 | GSK3B (0.48) | GSK3BPTPN1ATMCES1CES2 | |
| SCHEMBL3891431 | 1.00 | GSK3B (0.48) | GSK3BPTPN1ATMCES1CES2 | |
| Water SCHEMBL11163579 | 0.98 | GSK3B (0.46) | GSK3BPTPN1ATMCES1CES2 | |
| SCHEMBL2470468 | 0.78 | ATM (0.48) | ATMCES1CES2ALDH1A1HTT | |
| SCHEMBL8388578 | 0.77 | GSK3B (0.52) | GSK3BATMCES1CES2ALDH1A1 | |
| SCHEMBL11093317 | 0.77 | GSK3B (0.52) | GSK3BATMCES1CES2ALDH1A1 | |
| SCHEMBL11093321 | 0.77 | GSK3B (0.52) | GSK3BATMCES1CES2ALDH1A1 | |
| SCHEMBL28761026 | 0.77 | PTPN1 (0.52) | GSK3BPTPN1CES1CES2ALDH1A1 | |
| SCHEMBL6630645 | 0.76 | ATM (0.46) | ATMCES1ALDH1A1HTTGAA | |
| SCHEMBL9834835 | 0.76 | ATM (0.46) | ATMHTTGAACYP2C19DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9326930-B2 | Calcium sequestration compositions and methods of treating skin pigmentation disorders and conditions | NEOCUTIS S.A. (CH) | 2016-05-03 | — | — | US | disclosed |
| US-9326930-B2 | Calcium sequestration compositions and methods of treating skin pigmentation disorders and conditions | NEOCUTIS S.A. (CH) | 2016-05-03 | — | — | US | disclosed |
| US-9326930-B2 | Calcium sequestration compositions and methods of treating skin pigmentation disorders and conditions | NEOCUTIS S.A. (CH) | 2016-05-03 | — | — | US | disclosed |
| US-20160030321-A1 | CALCIUM SEQUESTRATION COMPOSITIONS AND METHODS OF TREATING SKIN PIGMENTATION DISORDERS AND CONDITIONS | NEOCUITIS S A (CH) | 2016-02-04 | — | — | US | disclosed |
| US-20160030321-A1 | CALCIUM SEQUESTRATION COMPOSITIONS AND METHODS OF TREATING SKIN PIGMENTATION DISORDERS AND CONDITIONS | NEOCUITIS S A (CH) | 2016-02-04 | — | — | US | disclosed |
| US-20160030321-A1 | CALCIUM SEQUESTRATION COMPOSITIONS AND METHODS OF TREATING SKIN PIGMENTATION DISORDERS AND CONDITIONS | NEOCUITIS S A (CH) | 2016-02-04 | — | — | US | disclosed |
| US-20140057334-A1 | AGENT THAT MODULATES PHYSIOLOGICAL CONDITION OF PESTS, INVOLVED IN INSECT CHOLINE ACETYLTRANSFERASE ACTIVITY | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2014-02-27 | — | — | US | disclosed |
| US-20140057334-A1 | AGENT THAT MODULATES PHYSIOLOGICAL CONDITION OF PESTS, INVOLVED IN INSECT CHOLINE ACETYLTRANSFERASE ACTIVITY | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2014-02-27 | — | — | US | disclosed |
| US-8476035-B2 | Agent that modulates physiological condition of pests, involved in insect choline acetyltransferase activity | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-07-02 | — | — | US | disclosed |
| US-8476035-B2 | Agent that modulates physiological condition of pests, involved in insect choline acetyltransferase activity | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-07-02 | — | — | US | disclosed |
| US-20110028423-A1 | AGENT THAT MODULATES PHYSIOLOGICAL CONDITION OF PESTS, INVOLVED IN INSECT CHOLINE ACETYLTRANSFERASE ACTIVITY | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-02-03 | — | — | US | disclosed |
| US-20110028423-A1 | AGENT THAT MODULATES PHYSIOLOGICAL CONDITION OF PESTS, INVOLVED IN INSECT CHOLINE ACETYLTRANSFERASE ACTIVITY | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-02-03 | — | — | US | disclosed |
| EP-0755923-B1 | Ameliorant or remedy for symptoms caused by Ischemic diseases and Phenylpiperidine compounds useful therefor | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2005-05-04 | — | — | EP | disclosed |
| US-6469010-B1 | COMPOSITION ALSO FOR ALLEVIATION OR TREATMENT OF SYMPTOMS DERIVED FROM SEIZURES, EPILEPSY AND MIGRAINE HEADACHES, AND SUPPRESSION OF CALCIUM ION OVERLOAD | SUNTORY LIMITED (JP) | 2002-10-22 | — | — | US | disclosed |
| US-6048876-A | ANTICONVULSANTS; ANTIEPILEPIC AGENT | SUNTORY LIMITED (JP) | 2000-04-11 | — | — | US | disclosed |
| EP-0755923-A1 | AMELIORANT OR REMEDY FOR SYMPTOMS CAUSED BY ISCHEMIC DISEASES AND COMPOUNDS USEFUL THEREFOR | SUNTORY LIMITED (JP) | 1997-01-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160030321-A1 | CALCIUM SEQUESTRATION COMPOSITIONS AND METHODS OF TREATING SKIN PIGMENTATION DISORDERS AND CONDITIONS | S100A4, TYR, CACYBP | GSK3B 1116/4885PTPN1 2741/4885ATM 4212/4885 |
| US-20110028423-A1 | AGENT THAT MODULATES PHYSIOLOGICAL CONDITION OF PESTS, INVOLVED IN INSECT CHOLINE ACETYLTRANSFERASE ACTIVITY | ACHE, CHAT, BCHE | GSK3B 4014/4885PTPN1 4070/4885ATM 2262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.