Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | FBP1 | P09467 | 13/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3786579 | 0.91 | FBP1 (0.54) | ALDH1A1FBP1THRBMAPTPOLB | |
| SCHEMBL2241502 | 0.89 | ALDH1A1 (0.43) | ALDH1A1FBP1THRBMAPTMEN1 | |
| SCHEMBL16413068 | 0.81 | THRB (0.42) | ALDH1A1FBP1THRBMAPTMEN1 | |
| SCHEMBL10081960 | 0.81 | THRB (0.44) | ALDH1A1FBP1THRBMAPTPOLB | |
| SCHEMBL22122423 | 0.81 | NPSR1 (0.47) | ALDH1A1FBP1THRBMAPTPOLB | |
| SCHEMBL23272323 | 0.80 | ALDH1A1 (0.52) | ALDH1A1FBP1POLBMEN1KMT2A | |
| SCHEMBL12352842 | 0.80 | S100A4 (0.38) | ALDH1A1FBP1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9034807 | 0.78 | FBP1 (0.56) | ALDH1A1FBP1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL6960 | 0.78 | ALDH1A1 (0.56) | ALDH1A1MAPTPOLBMEN1KMT2A | |
| SCHEMBL13733088 | 0.78 | THRB (0.42) | ALDH1A1FBP1THRBMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389511-B2 | Bicyclic heterocyclic derivative | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2013-03-05 | — | — | US | disclosed |