Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.68 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | XBP1 | P17861 | 1/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.56 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfamide SCHEMBL7137771 | 0.90 | PTGS2 (0.79) | PTGS2PTGS1NPC1RAB9AALDH1A1 | |
| SCHEMBL6157378 | 0.88 | PTGS2 (0.63) | PTGS2PTGS1NPC1RAB9AALDH1A1 | |
| SCHEMBL213767 | 0.82 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL8765028 | 0.81 | HIF1A (0.55) | PTGS2PTGS1NPC1RAB9AALDH1A1 | |
| SCHEMBL7912407 | 0.78 | NPC1 (0.65) | PTGS2PTGS1NPC1RAB9AALDH1A1 | |
| SCHEMBL31276196 | 0.77 | LMNA (0.56) | PTGS2PTGS1NPC1RAB9AALDH1A1 | |
| SCHEMBL14495383 | 0.77 | ALDH1A1 (0.50) | PTGS2PTGS1NPC1RAB9AALDH1A1 | |
| SCHEMBL22795877 | 0.77 | NPC1 (0.49) | PTGS2PTGS1NPC1RAB9AALDH1A1 | |
| SCHEMBL14747808 | 0.77 | PTGS2 (0.68) | PTGS2PTGS1NPC1RAB9AALDH1A1 | |
| SCHEMBL12854139 | 0.77 | HIF1A (0.69) | PTGS2PTGS1NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109890822-A | INHIBITORS OF CELLULAR METABOLIC PROCESSES | 安吉奥斯医药品有限公司 | 2019-06-14 | — | — | CN | disclosed |
| US-RE44048-E1 | 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-YL]benzenesulfonamide for the treatment of inflammation or an inflammation-associated disorder | G.D. SEARLE LLC (US) | 2013-03-05 | — | — | US | disclosed |