Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | FOS | P01100 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | JUN | P05412 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14747869 | 0.82 | HTR1A (0.41) | HTR1APPARGPPARASTAT3SIGMAR1 | |
| SCHEMBL14747877 | 0.82 | HTR1A (0.56) | HTR1APPARGPPARASTAT3TUBB4A | |
| SCHEMBL12020315 | 0.80 | SKP2 (0.53) | HTR1APPARGPPARATUBB4ATUBB | |
| SCHEMBL15760679 | 0.78 | TUBB4A (0.53) | PPARGPPARATUBB4ATUBBTUBA3C | |
| SCHEMBL21755693 | 0.78 | HTR1A (0.59) | HTR1APPARGPPARASTAT3TUBB4A | |
| Benzene SCHEMBL2920819 | 0.77 | PPARG (0.54) | PPARGPPARA | |
| SCHEMBL23428645 | 0.77 | HTR1A (0.61) | HTR1APPARGPPARASTAT3TUBB4A | |
| SCHEMBL17637575 | 0.77 | TUBB4A (0.51) | PPARGPPARATUBB4ATUBBTUBA3C | |
| SCHEMBL2559405 | 0.77 | ATM (0.48) | PPARGPPARAKDM4EATMALDH1A1 | |
| SCHEMBL103861 | 0.76 | STAT3 (0.50) | HTR1ASTAT3SIGMAR1KDM4EATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2275413-B1 | 2,4-di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | NOVARTIS AG (CH) | 2013-03-06 | — | — | EP | disclosed |