Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.59 |
| ▸ | LTA4H | P09960 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.48 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23428645 | 0.99 | HTR1A (0.61) | HTR1ALTA4HCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL14747877 | 0.96 | HTR1A (0.56) | HTR1ALTA4HCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL19389985 | 0.82 | HTR1A (0.47) | HTR1ALTA4HCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL15760679 | 0.82 | TUBB4A (0.53) | CYP3A4CYP1A2CYP2D6PPARGPPARA | |
| SCHEMBL23370746 | 0.81 | HTR1A (0.87) | HTR1ALTA4HCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL12020315 | 0.80 | SKP2 (0.53) | HTR1ACYP3A4CYP2C8CYP2C9CYP2B6 | |
| SCHEMBL17637575 | 0.80 | TUBB4A (0.51) | CYP3A4CYP1A2CYP2D6PPARGPPARA | |
| SCHEMBL5702631 | 0.80 | HTR1A (0.90) | HTR1ALTA4HCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL14747866 | 0.79 | TUBB4A (0.43) | HTR1ACYP3A4TRPV1STAT3PPARG | |
| SCHEMBL14747869 | 0.79 | HTR1A (0.41) | HTR1ALTA4HCYP3A4CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10570154-B2 | Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10570154-B2 | Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders | BRSK2, STK3, BRSK1 | HTR1A 2218/4885LTA4H 4260/4885CYP3A4 3981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.