Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12178129 | 0.82 | KDM4E (0.44) | KDM4ESMN1; SMN2NPSR1ALDH1A1HPGD | |
| SCHEMBL14735299 | 0.80 | ALDH1A1 (0.44) | KDM4ESMN1; SMN2NPSR1ALDH1A1HPGD | |
| SCHEMBL784919 | 0.77 | CYP3A4 (0.36) | KDM4EALDH1A1GAAPOLBLMNA | |
| SCHEMBL6341931 | 0.76 | AOC3 (0.43) | KDM4ESMN1; SMN2NPSR1ALDH1A1HPGD | |
| SCHEMBL6989495 | 0.73 | LMNA (0.46) | ALDH1A1HPGDHSD17B10TDP1LMNA | |
| SCHEMBL773047 | 0.73 | KDM4E (0.51) | KDM4ESMN1; SMN2NPSR1ALDH1A1HPGD | |
| SCHEMBL11695496 | 0.73 | ALDH1A1 (0.55) | KDM4ESMN1; SMN2NPSR1ALDH1A1HPGD | |
| SCHEMBL1027211 | 0.72 | AOC3 (0.43) | KDM4ESMN1; SMN2NPSR1ALDH1A1HPGD | |
| SCHEMBL14883951 | 0.72 | ALDH1A1 (0.48) | KDM4ESMN1; SMN2NPSR1ALDH1A1HPGD | |
| SCHEMBL1748291 | 0.71 | KDM4E (0.43) | KDM4ESMN1; SMN2NPSR1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2565192-B9 | ANTICANCER AGENT | UNIV TOKYO (JP) | 2015-11-25 | — | — | EP | disclosed |
| EP-2565192-B1 | ANTICANCER AGENT | UNIV TOKYO (JP) | 2015-08-12 | — | — | EP | disclosed |
| EP-2565192-A1 | ANTICANCER AGENT | The University of Tokyo (JP) | 2013-03-06 | — | — | EP | disclosed |