SCHEMBL6989495

SCHEMBL6989495

Cc1c(O)c(C=O)cc2c1OCO2

nearest known ligand 0.46

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.46
HPGD P15428 1/20 0.46
ERN1 O75460 12/20 0.44
ALDH1A1 P00352 2/20 0.38
MAPT P10636 1/20 0.38
HSD17B10 Q99714 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
NQO2 P16083 2/20 0.35
CYP19A1 P11511 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9908795 0.82 CYP3A4 (0.40) LMNAHPGDALDH1A1MAPT
SCHEMBL784919 0.77 CYP3A4 (0.36) LMNAALDH1A1MAPTNQO2CYP19A1
SCHEMBL2232816 0.75 ALDH1A1 (0.45) LMNAHPGDERN1ALDH1A1MAPT
SCHEMBL12553097 0.74 LMNA (0.46) LMNAHPGDERN1ALDH1A1MAPT
SCHEMBL14747985 0.73 KDM4E (0.46) LMNAHPGDALDH1A1HSD17B10TDP1
SCHEMBL10430741 0.72 ERN1 (0.44) LMNAHPGDERN1ALDH1A1MAPT
SCHEMBL14070022 0.71 LMNA (0.64) LMNAHPGDERN1ALDH1A1MAPT
SCHEMBL30705750 0.71 ERN1 (0.65) ERN1
SCHEMBL14284000 0.71 CYP3A4 (0.38) ALDH1A1NQO2CYP19A1
SCHEMBL30634677 0.71 LMNA (0.55) LMNAHPGDERN1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0931083-B1 PROCESS FOR PRODUCING ECTEINASCIDIN COMPOUNDS HARVARD COLLEGE (US) 2003-02-19 EP disclosed
EP-0931083-A4 PROCESS FOR PRODUCING ECTEINASCIDIN COMPOUNDS HARVARD COLLEGE (US) 2000-05-24 EP disclosed
EP-0931083-A1 PROCESS FOR PRODUCING ECTEINASCIDIN COMPOUNDS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1999-07-28 EP disclosed
WO-1998012198-A1 PROCESS FOR PRODUCING ECTEINASCIDIN COMPOUNDS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1998-03-26 WO disclosed
US-5721362-A Process for producing ecteinascidin compounds PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1998-02-24 US disclosed