Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GALR2 | O43603 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6634074 | 0.81 | ALDH1A1 (0.57) | POLBLMNAGALR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL2267794 | 0.81 | POLB (0.51) | POLBLMNAGALR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL30807120 | 0.81 | ALDH1A1 (0.57) | POLBLMNAGALR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL790395 | 0.79 | POLB (0.50) | POLBLMNAGALR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL6832051 | 0.79 | POLB (0.50) | POLBLMNAGALR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL28897809 | 0.77 | POLB (0.47) | POLBLMNAGALR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL15828585 | 0.77 | LMNA (0.47) | POLBLMNAGALR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL7878609 | 0.77 | SMN1; SMN2 (0.39) | POLBLMNAGALR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL13259319 | 0.76 | MAPT (0.43) | POLBLMNASMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL2684241 | 0.76 | HCAR3 (0.55) | POLBLMNAGALR2ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183232-B1 | PI3 KINASE MODULATORS AND METHODS OF USE | AMGEN INC (US) | 2013-03-06 | — | — | EP | disclosed |