Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14748435 | 0.83 | CRHBP (0.40) | PRKDCLMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL19622259 | 0.82 | LMNA (0.41) | PRKDCLMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL14748439 | 0.78 | ALDH1A1 (0.38) | PRKDCLMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4253285 | 0.71 | PRKDC (0.75) | PRKDCLMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL10102093 | 0.67 | PRKDC (0.53) | PRKDCLMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL670086 | 0.67 | LMNA (0.77) | PRKDCLMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL20157967 | 0.67 | PRKDC (0.47) | PRKDCLMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL10018128 | 0.66 | PRKDC (0.54) | PRKDCLMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL19622180 | 0.65 | HAO1 (0.33) | PRKDCALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL28521484 | 0.65 | PRKDC (0.50) | PRKDCLMNAALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2564857-A1 | Boron-containing small molecules as anti-inflammatory agents | Anacor Pharmaceuticals, Inc. (US) | 2013-03-06 | — | — | EP | disclosed |