Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | FBP1 | P09467 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14750665 | 0.73 | PPARA (0.48) | GAAMAPTALDH1A1CNR2SMN1; SMN2 | |
| SCHEMBL14749778 | 0.73 | L3MBTL1 (0.44) | GAAMAPTALDH1A1CNR2SMN1; SMN2 | |
| SCHEMBL14749777 | 0.72 | CYP2C9 (0.55) | GAAMAPTALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL16784834 | 0.70 | ALDH1A1 (0.52) | GAAMAPTALDH1A1L3MBTL1POLB | |
| SCHEMBL16784835 | 0.65 | SMN1; SMN2 (0.53) | GAAMAPTALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL10806123 | 0.64 | MAPT (0.42) | GAAMAPTALDH1A1CNR2SMN1; SMN2 | |
| SCHEMBL21753940 | 0.64 | ALDH1A1 (0.43) | GAAMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL16784850 | 0.64 | PPARA (0.46) | GAAMAPTALDH1A1CNR2SMN1; SMN2 | |
| SCHEMBL14750650 | 0.63 | ALDH1A1 (0.41) | GAAMAPTALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL14749776 | 0.63 | L3MBTL1 (0.42) | GAAMAPTALDH1A1SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130059853-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059853-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | PDE3B, PDE3A, PDE4A | GAA 202/4885MAPT 4737/4885ALDH1A1 824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.