Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MIF | P14174 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6129096 | 0.86 | POLB (0.65) | SMN1; SMN2POLBPDE4DALDH1A1HPGD | |
| SCHEMBL6743332 | 0.83 | POLB (0.62) | SMN1; SMN2POLBALDH1A1HPGDMIF | |
| SCHEMBL16784834 | 0.83 | ALDH1A1 (0.52) | POLBALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL1434844 | 0.82 | PDE4D (0.60) | SMN1; SMN2POLBPDE4DALDH1A1HPGD | |
| SCHEMBL16784832 | 0.82 | ALOX15 (0.58) | SMN1; SMN2POLBPDE4DALDH1A1HPGD | |
| SCHEMBL29184862 | 0.81 | PDE4D (0.58) | SMN1; SMN2POLBPDE4DALDH1A1HPGD | |
| SCHEMBL885177 | 0.80 | PDE4D (0.57) | SMN1; SMN2POLBPDE4DALDH1A1HPGD | |
| SCHEMBL14060872 | 0.79 | L3MBTL1 (0.47) | SMN1; SMN2POLBKMT2AKDM4ETDP1 | |
| SCHEMBL6744642 | 0.79 | SMN1; SMN2 (0.70) | SMN1; SMN2POLBALDH1A1HPGDKMT2A | |
| SCHEMBL14749777 | 0.78 | CYP2C9 (0.55) | SMN1; SMN2ALDH1A1KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051290-B2 | Biaryl phosphodiesterase inhibitors | LEO PHARMA A/S (DK) | 2015-06-09 | — | — | US | disclosed |