Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.54 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3049706 | 1.00 | CHRNA7 (0.54) | CHRNA7REV1KDM4EGLARCE1 | |
| Hydrochloric Acid SCHEMBL30842786 | 0.99 | CHRNA7 (0.53) | CHRNA7REV1KDM4EGLARCE1 | |
| Hydrochloric Acid SCHEMBL28460391 | 0.99 | CHRNA7 (0.53) | CHRNA7REV1KDM4EGLARCE1 | |
| SCHEMBL22997884 | 0.90 | AOC3 (0.43) | CHRNA7KDM4EMAPK1HSD17B10 | |
| SCHEMBL31268130 | 0.82 | MAOA (0.47) | CHRNA7KDM4EGLARCE1HSD17B10 | |
| SCHEMBL251439 | 0.82 | MAOA (0.47) | CHRNA7KDM4EGLARCE1HSD17B10 | |
| SCHEMBL17144907 | 0.82 | MAOA (0.47) | CHRNA7KDM4EGLARCE1HSD17B10 | |
| SCHEMBL28933503 | 0.81 | PDE4D (0.44) | KDM4EGLAMAPK1HSD17B10 | |
| SCHEMBL30019618 | 0.81 | PDE4D (0.44) | KDM4EGLAMAPK1HSD17B10 | |
| Hydrochloric Acid SCHEMBL4772044 | 0.80 | MAOA (0.46) | CHRNA7KDM4EGLARCE1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552028-B2 | 8-phenylisoquinolines and pharmaceutical composition used in treatment for sepsis | NATIONAL TAIWAN UNIVERSITY (TW) | 2013-10-08 | — | — | US | disclosed |
| US-20130059882-A1 | 8-Phenylisoquinolines And Pharmaceutical Composition Used In Treatment For Sepsis | NATIONAL TAIWAN UNIVERSITY (TW) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059882-A1 | 8-Phenylisoquinolines And Pharmaceutical Composition Used In Treatment For Sepsis | CXCL8, THPO, IL18 | CHRNA7 2982/4885REV1 3779/4885KDM4E 3539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.