SCHEMBL14756103

SCHEMBL14756103

COc1ccc2c(c1)C(c1ccc(Cl)cc1)=NCc1nnc(C)n1-2

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.69
SMN1; SMN2 Q16637 2/20 0.69
ALDH1A1 P00352 1/20 0.69
BRD4 O60885 12/20 0.69
GABRA1 P14867 6/20 0.69
GABRA5 P31644 6/20 0.69
GABRA2 P47869 6/20 0.69
GABRB2 P47870 5/20 0.69
GABRA3 P34903 4/20 0.69
HPGD P15428 2/20 0.69
OPRK1 P41145 2/20 0.69
CNR1 P21554 1/20 0.69
GABRG2 P18507 1/20 0.61
HTR2A P28223 1/20 0.61
GABRB3 P28472 1/20 0.61
ADRA1A P35348 1/20 0.61
PDE4D Q08499 1/20 0.61
TSHR P16473 1/20 0.53
PTAFR P25105 1/20 0.53
BRD2 P25440 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11636791 0.93 GABRA1 (0.76) LMNASMN1; SMN2ALDH1A1BRD4GABRA1
SCHEMBL23109728 0.91 LMNA (0.60) LMNASMN1; SMN2ALDH1A1BRD4GABRA1
SCHEMBL7318994 0.89 GABRA1 (0.71) LMNASMN1; SMN2ALDH1A1BRD4GABRA1
SCHEMBL16771529 0.86 GABRA1 (0.61) LMNASMN1; SMN2ALDH1A1BRD4GABRA1
SCHEMBL14756888 0.84 GABRA1 (0.71) LMNASMN1; SMN2ALDH1A1BRD4GABRA1
SCHEMBL9378858 0.84 GABRA1 (0.71) LMNASMN1; SMN2ALDH1A1BRD4GABRA1
SCHEMBL14757175 0.84 BRD4 (0.59) LMNASMN1; SMN2ALDH1A1BRD4GABRA1
Alprazolam SCHEMBL16922178 0.81 GABRA1 (1.00) LMNASMN1; SMN2ALDH1A1BRD4GABRA1
Alprazolam SCHEMBL8398 0.81 GABRA1 (1.00) LMNASMN1; SMN2ALDH1A1BRD4GABRA1
Alprazolam SCHEMBL5480614 0.81 GABRA1 (1.00) LMNASMN1; SMN2ALDH1A1BRD4GABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023192642-A2 METHODS AND COMPOUNDS FOR MODULATING HUNTINGTON'S DISEASE Design Therapeutics, Inc. (US) 2023-10-05 WO disclosed
US-20230285570-A1 THERAPEUTICALLY USEFUL CURE-PRO MOLECULES FOR E3 LIGASE MEDIATED DEGRADATION OF PROTEINS, AND METHODS OF MAKING AND USING THEM CORNELL UNIVERSITY 2023-09-14 US disclosed
EP-3256470-B1 METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES DANA FARBER CANCER INST INC (US) 2023-07-26 EP disclosed
US-20230183209-A1 CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME ARVINAS OPERATIONS, INC. (US) 2023-06-15 US disclosed
WO-2022150555-A2 METHODS AND COMPOUNDS FOR TREATING FRIEDREICH'S ATAXIA Design Therapeutics, Inc. (US) 2022-07-14 WO disclosed
WO-2021183431-A1 FEM1B PROTEIN BINDING AGENTS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-09-16 WO disclosed
WO-2021158707-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. (US) 2021-08-12 WO disclosed
EP-3778590-A1 PROTEIN DEGRADATION TARGETING COMPOUND, ANTI-TUMOR APPLICATION, INTERMEDIATE THEREOF AND USE OF INTERMEDIATE ShanghaiTech University (CN) 2021-02-17 EP disclosed
WO-2019183523-A1 HETERO-BIFUNCTIONAL DEGRADER COMPOUNDS AND THEIR USE AS MODULATORS OF TARGETED UBIQUINATION (VHL) GENENTECH, INC. (US) 2019-09-26 WO disclosed
EP-3129378-B1 BROMODOMAIN-INHIBITING COMPOUNDS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FOR PREVENTING OR TREATING A CANCER KAINOS MEDICINE INC (KR) 2019-06-26 EP disclosed
US-20180215731-A1 CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME ARVINAS OPERATIONS, INC. 2018-08-02 US disclosed
EP-3050885-B1 BENZODIAZEPINE BROMODOMAIN INHIBITOR GLAXOSMITHKLINE LLC (US) 2017-10-18 EP disclosed
WO-2017157813-A1 COMBINATIONS OF LSD1 INHIBITORS FOR THE TREATMENT OF HEMATOLOGICAL MALIGNANCIES F. HOFFMANN-LA ROCHE AG (CH) 2017-09-21 WO disclosed
US-20170145021-A1 NOVEL COMPOUNDS GLAXOSMITHKLINE LLC 2017-05-25 US disclosed
US-20150210706-A1 Benzodiazepine Bromodomain Inhibitor GLAXOSMITHKLINE LLC 2015-07-30 US disclosed
WO-2013033270-A2 BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME COFERON, INC. (US) 2013-03-07 WO disclosed
WO-2013033269-A1 BIOORTHOGONAL MONOMERS CAPABLE OF DIMERIZING AND TARGETING BROMODOMAINS AND METHODS OF USING SAME COFERON, INC. (US) 2013-03-07 WO disclosed
WO-2013033268-A2 BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME COFERON, INC. (US) 2013-03-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230183209-A1 CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME CRBN, CBL, MDM2 LMNA 3085/4885SMN1; SMN2 1838/4885ALDH1A1 3671/4885
US-20230285570-A1 THERAPEUTICALLY USEFUL CURE-PRO MOLECULES FOR E3 LIGASE MEDIATED DEGRADATION OF PROTEINS, AND METHODS OF MAKING AND USING THEM XIAP, CUL4A, CUL1 LMNA 1674/4885SMN1; SMN2 1805/4885ALDH1A1 2592/4885
US-20170145021-A1 NOVEL COMPOUNDS GABRE, GABRA1, GABRA6 LMNA 2687/4885SMN1; SMN2 1660/4885ALDH1A1 996/4885
US-20180215731-A1 CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME CRBN, CBL, MDM2 LMNA 3085/4885SMN1; SMN2 1838/4885ALDH1A1 3671/4885
US-20150210706-A1 Benzodiazepine Bromodomain Inhibitor BRD4, BRD3, BRD2 LMNA 2021/4885SMN1; SMN2 3578/4885ALDH1A1 1782/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.