Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Alprazolam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 7/20 | 1.00 |
| ▸ | GABRA5 known ✓ | P31644 | 7/20 | 1.00 |
| ▸ | GABRA2 known ✓ | P47869 | 7/20 | 1.00 |
| ▸ | GABRB2 known ✓ | P47870 | 6/20 | 1.00 |
| ▸ | GABRA3 known ✓ | P34903 | 5/20 | 1.00 |
| ▸ | GABRG2 known ✓ | P18507 | 2/20 | 0.77 |
| ▸ | GABRB3 known ✓ | P28472 | 2/20 | 0.77 |
| ▸ | GABRP known ✓ | O00591 | 1/20 | 0.58 |
| ▸ | GABRD known ✓ | O14764 | 1/20 | 0.58 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.58 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 0.58 |
| ▸ | GABRE known ✓ | P78334 | 1/20 | 0.58 |
| ▸ | GABRA6 known ✓ | Q16445 | 1/20 | 0.58 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 1/20 | 0.58 |
| ▸ | GABRG3 known ✓ | Q99928 | 1/20 | 0.58 |
| ▸ | GABRQ known ✓ | Q9UN88 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 5/20 | 1.00 |
| ▸ | HPGD | P15428 | 4/20 | 1.00 |
| ▸ | BRD4 | O60885 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alprazolam SCHEMBL29381667 | 1.00 | GABRA1 (1.00) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| Alprazolam SCHEMBL8398 | 1.00 | GABRA1 (1.00) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| Alprazolam SCHEMBL5480614 | 1.00 | GABRA1 (1.00) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| Alprazolam SCHEMBL22527891 | 0.99 | GABRA1 (0.98) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| Alprazolam SCHEMBL28964138 | 0.99 | GABRA1 (0.98) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| Alprazolam SCHEMBL2420072 | 0.91 | GABRA1 (0.82) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| Alprazolam SCHEMBL4973049 | 0.91 | GABRA1 (0.82) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| SCHEMBL7323630 | 0.89 | OPRK1 (0.80) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| SCHEMBL11825281 | 0.88 | OPRK1 (0.78) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| Triazolam SCHEMBL29228 | 0.87 | GABRA1 (1.00) | GABRA1GABRA5GABRA2GABRB2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9347961-B2 | Test kit for the quantitative determination of narcotic drugs | CHIRON AS (NO) | 2016-05-24 | — | — | US | disclosed |
| US-20150204893-A1 | TEST KIT FOR THE QUANTITATIVE DETERMINATION OF NARCOTIC DRUGS | CHIRON AS (NO) | 2015-07-23 | — | — | US | disclosed |