Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.34 |
| ▸ | METAP1 | P53582 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | DRD5 | P21918 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2321700 | 0.83 | LMNA (0.36) | LMNAHRH3METAP1ALDH1A1KCNH2 | |
| SCHEMBL4525699 | 0.72 | DRD4 (0.32) | HRH3SIGMAR1DRD1DRD5DRD2 | |
| SCHEMBL2321696 | 0.68 | HTR7 (0.38) | LMNAMEN1KMT2ADRD2 | |
| SCHEMBL6195562 | 0.67 | DRD2 (0.49) | MEN1KMT2ADRD2 | |
| SCHEMBL1777323 | 0.65 | CHRM5 (0.38) | METAP1OPRM1OPRK1OPRL1 | |
| SCHEMBL8061014 | 0.65 | GAA (0.59) | SIGMAR1MEN1ALDH1A1KMT2ADRD2 | |
| SCHEMBL1778000 | 0.64 | CHRM5 (0.41) | HRH3METAP1OPRM1OPRK1OPRL1 | |
| SCHEMBL27738412 | 0.64 | CHRM5 (0.41) | HRH3METAP1OPRM1OPRK1OPRL1 | |
| SCHEMBL1776075 | 0.64 | CHRM5 (0.41) | HRH3METAP1OPRM1OPRK1OPRL1 | |
| SCHEMBL1776362 | 0.64 | CHRM5 (0.41) | HRH3METAP1OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558578-B1 | NOVEL ALKYNE COMPOUNDS HAVING AN MCH ANTAGONISTIC EFFECT AND MEDICAMENTS CONTAINING THESE COMPOUNDS | BOEHRINGER INGELHEIM PHARMA (DE) | 2013-03-13 | — | — | EP | disclosed |