Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL516132 | 0.92 | CYP3A4 (0.52) | CYP3A4TSHRCYP1A2CYP2D6MAPK1 | |
| SCHEMBL516778 | 0.78 | HPGD (0.42) | CYP3A4TSHRCYP1A2CYP2D6MAPK1 | |
| SCHEMBL515685 | 0.77 | CYP3A4 (0.46) | CYP3A4TSHRCYP1A2CYP2D6MAPK1 | |
| SCHEMBL515694 | 0.77 | ALDH1A1 (0.43) | CYP3A4TSHRCYP1A2CYP2D6MAPK1 | |
| SCHEMBL515952 | 0.77 | POLB (0.43) | CYP3A4TSHRCYP1A2CYP2D6MAPK1 | |
| SCHEMBL516110 | 0.77 | OPRM1 (0.43) | OPRD1 | |
| SCHEMBL515948 | 0.77 | SLC6A2 (0.41) | CYP3A4TSHRCYP1A2CYP2D6MAPK1 | |
| SCHEMBL515667 | 0.75 | CYP1A2 (0.47) | CYP3A4TSHRCYP1A2CYP2D6MAPK1 | |
| SCHEMBL516182 | 0.75 | L3MBTL1 (0.43) | CYP3A4TSHRCYP1A2CYP2D6MAPK1 | |
| SCHEMBL516137 | 0.74 | GPR88 (0.39) | CYP3A4TSHRCYP1A2CYP2D6MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455550-B2 | Derivatives of aminocyclobutane or aminocyclobutene, their method of preparation and their use as medical products | PIERRE FABRE MEDICAMENT (FR) | 2013-06-04 | — | — | US | disclosed |
| EP-2414323-B1 | DERIVATIVES OF AMINOCYCLOBUTANE OR AMINOCYCLOBUTENE, THEIR METHOD OF PREPARATION AND THEIR USE AS MEDICAL PRODUCTS | PF MEDICAMENT (FR) | 2013-03-13 | — | — | EP | disclosed |