Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.35 |
| ▸ | MAP3K7 | O43318 | 5/20 | 0.35 |
| ▸ | TAB1 | Q15750 | 5/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14764120 | 1.00 | KDM5A (0.39) | KDM5ALRRK2PIK3CAPIK3CDPIK3CB | |
| SCHEMBL14764038 | 1.00 | KDM5A (0.39) | KDM5ALRRK2PIK3CAPIK3CDPIK3CB | |
| SCHEMBL173506 | 0.90 | — | — | |
| SCHEMBL16513526 | 0.89 | KDM5A (0.38) | KDM5ALRRK2PIK3CAPIK3CDPIK3CB | |
| Hydrochloric Acid SCHEMBL25243994 | 0.88 | PIK3CD (0.41) | KDM5APIK3CAPIK3CDPIK3CBPI4KA | |
| Hydrochloric Acid SCHEMBL31507950 | 0.88 | PIK3CD (0.41) | KDM5APIK3CAPIK3CDPIK3CBPI4KA | |
| SCHEMBL28159841 | 0.83 | PIK3CD (0.38) | KDM5APIK3CAPIK3CDPIK3CBPI4KA | |
| SCHEMBL16764416 | 0.82 | ACHE (0.47) | KDM5APIK3CAPIK3CDPIK3CBPI4KA | |
| SCHEMBL1703023 | 0.82 | ACHE (0.44) | KDM5ALRRK2PIK3CAPIK3CDPIK3CB | |
| SCHEMBL15197725 | 0.81 | KDM5A (0.39) | KDM5APIK3CAPIK3CDPIK3CBPI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230028584-A1 | ATF6 MODULATORS AND USES THEREOF | ALTOS LABS, INC. | 2023-01-26 | — | — | US | disclosed |
| CN-115087656-A | ATF6 modulators and uses thereof | 普拉西斯生物技术有限责任公司 | 2022-09-20 | — | — | CN | disclosed |
| EP-4041728-A1 | ATF6 MODULATORS AND USES THEREOF | Praxis Biotech LLC (US) | 2022-08-17 | — | — | EP | disclosed |
| WO-2021069721-A1 | ATF6 MODULATORS AND USES THEREOF | BLACK BELT TX LTD (GB) | 2021-04-15 | — | — | WO | disclosed |
| US-20190135836-A1 | HETEROCYCLIC KINASE INHIBITORS | ABBVIE INC (US) | 2019-05-09 | — | — | US | disclosed |
| US-20190135836-A1 | HETEROCYCLIC KINASE INHIBITORS | ABBVIE INC (US) | 2019-05-09 | — | — | US | disclosed |
| US-10280184-B2 | Heterocyclic kinase inhibitors | ABBVIE INC. (US) | 2019-05-07 | — | — | US | disclosed |
| US-10280184-B2 | Heterocyclic kinase inhibitors | ABBVIE INC. (US) | 2019-05-07 | — | — | US | disclosed |
| US-20170114077-A1 | HETEROCYCLIC KINASE INHIBITORS | ABBVIE INC. | 2017-04-27 | — | — | US | disclosed |
| US-20170114077-A1 | HETEROCYCLIC KINASE INHIBITORS | ABBVIE INC. | 2017-04-27 | — | — | US | disclosed |
| US-20170114077-A1 | HETEROCYCLIC KINASE INHIBITORS | ABBVIE INC. | 2017-04-27 | — | — | US | disclosed |
| WO-2015158283-A1 | HETEROCYCLIC KINASE INHIBITORS | ABBVIE INC. (US) | 2015-10-22 | — | — | WO | disclosed |
| US-8969335-B2 | Benzonitrile derivatives as kinase inhibitors | MERCK PATENT GMBH (DE) | 2015-03-03 | — | — | US | disclosed |
| US-20140228340-A1 | BENZONITRILE DERIVATIVES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2014-08-14 | — | — | US | disclosed |
| WO-2013034238-A1 | BENZONITRILE DERIVATIVES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2013-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10280184-B2 | Heterocyclic kinase inhibitors | MAP3K1, MAP3K20, MAP3K19 | KDM5A 1333/4885LRRK2 1283/4885PIK3CA 73/4885 |
| US-20140228340-A1 | BENZONITRILE DERIVATIVES AS KINASE INHIBITORS | TBK1, NFKBIA, IKBKG | KDM5A 1773/4885LRRK2 388/4885PIK3CA 667/4885 |
| US-20170114077-A1 | HETEROCYCLIC KINASE INHIBITORS | MAP3K1, MAP3K20, MAP3K19 | KDM5A 1333/4885LRRK2 1283/4885PIK3CA 73/4885 |
| US-20230028584-A1 | ATF6 MODULATORS AND USES THEREOF | ATF4, XBP1, ATF1 | KDM5A 4815/4885LRRK2 1111/4885PIK3CA 1513/4885 |
| US-20190135836-A1 | HETEROCYCLIC KINASE INHIBITORS | MAP3K1, MAP3K20, MAP3K19 | KDM5A 1377/4885LRRK2 1329/4885PIK3CA 71/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.