Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14764430 | 0.93 | MAPT (0.41) | MAPTKDM4EALDH1A1RAB9APOLB | |
| SCHEMBL14764633 | 0.83 | MAPT (0.41) | MAPTKDM4EALDH1A1RAB9APOLB | |
| SCHEMBL14764490 | 0.83 | ALDH1A1 (0.41) | MAPTKDM4EALDH1A1RAB9APOLB | |
| SCHEMBL14764689 | 0.80 | NQO2 (0.56) | MAPTKDM4EALDH1A1RAB9APOLB | |
| SCHEMBL12503018 | 0.79 | MAPT (0.58) | MAPTKDM4EALDH1A1RAB9APOLB | |
| SCHEMBL8604288 | 0.78 | MAPT (0.52) | MAPTKDM4EALDH1A1RAB9APOLB | |
| SCHEMBL14764528 | 0.76 | MAPT (0.41) | MAPTKDM4EALDH1A1RAB9APOLB | |
| SCHEMBL14764541 | 0.76 | ALDH1A1 (0.37) | MAPTKDM4EALDH1A1RAB9APOLB | |
| SCHEMBL20475325 | 0.76 | RAB9A (0.53) | MAPTALDH1A1RAB9APOLBMAPK1 | |
| SCHEMBL31643056 | 0.76 | RAB9A (0.53) | MAPTALDH1A1RAB9APOLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013034758-A1 | SUBSTITUTED TRIAZOLOPYRAZINES AND USES THEREOF | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |