Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 5/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16052812 | 0.84 | PDE3B (0.43) | NQO2PDE3BPDE3AGRIN2DGRIN3B | |
| SCHEMBL16053154 | 0.82 | PDE3B (0.38) | NQO2PDE3BPDE3AGRIN2DGRIN3B | |
| SCHEMBL14765195 | 0.76 | ALDH1A1 (0.45) | NQO2PDE3BPDE3AALDH1A1PRNP | |
| SCHEMBL14765103 | 0.75 | NQO2 (0.45) | NQO2PDE3BPDE3AALDH1A1MAPT | |
| SCHEMBL31426154 | 0.73 | TYMS (0.34) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL16053360 | 0.71 | XDH (0.39) | ALDH1A1MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL14765128 | 0.70 | NQO2 (0.42) | NQO2PDE3BPDE3AMAPTGRIN2D | |
| SCHEMBL25377211 | 0.69 | DAO (0.35) | PDE3BPDE3AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL1318287 | 0.69 | RXFP1 (0.37) | NQO2PDE3BPDE3AALDH1A1PRNP | |
| SCHEMBL31049738 | 0.69 | DAO (0.35) | PDE3BPDE3AGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014139983-A1 | [1,2,4]TRIAZOLO[4,3-A]QUINOXALINES AS DUAL PDE2/PDE10 INHIBITORS | H. LUNDBECK A/S (DK) | 2014-09-18 | — | — | WO | disclosed |
| WO-2013034758-A1 | SUBSTITUTED TRIAZOLOPYRAZINES AND USES THEREOF | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |