SCHEMBL147658

SCHEMBL147658

O=C(CBr)Nc1ccon1

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GAPDH P04406 1/20 0.56
L3MBTL1 Q9Y468 2/20 0.52
KMT2A Q03164 2/20 0.50
ATM Q13315 1/20 0.50
KDM4E B2RXH2 3/20 0.49
ALDH1A1 P00352 2/20 0.49
RXFP1 Q9HBX9 1/20 0.49
RAB9A P51151 3/20 0.49
NPC1 O15118 1/20 0.49
POLB P06746 2/20 0.49
SMN1; SMN2 Q16637 3/20 0.47
GAA P10253 1/20 0.47
HPGD P15428 2/20 0.47
HTT P42858 2/20 0.47
LMNA P02545 1/20 0.46
MEN1 O00255 1/20 0.46
CASP1 P29466 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9912435 0.83 GAPDH (0.58) GAPDHL3MBTL1KMT2AATMKDM4E
SCHEMBL1428340 0.81 GAPDH (0.56) GAPDHL3MBTL1KMT2AATMKDM4E
SCHEMBL4109619 0.81 ATM (0.58) GAPDHL3MBTL1KMT2AATMKDM4E
SCHEMBL13149779 0.79 GAPDH (0.57) GAPDHL3MBTL1KMT2AATMKDM4E
SCHEMBL13059408 0.79 ATM (0.59) GAPDHL3MBTL1ATMKDM4EALDH1A1
Hydrochloric Acid SCHEMBL3090336 0.77 GAPDH (0.56) GAPDHL3MBTL1KMT2AATMKDM4E
SCHEMBL13002465 0.77 GAPDH (0.52) GAPDHL3MBTL1KMT2AATMKDM4E
SCHEMBL19116648 0.77 SMN1; SMN2 (0.58) GAPDHL3MBTL1ATMALDH1A1RAB9A
SCHEMBL1033633 0.77 GAPDH (0.52) GAPDHL3MBTL1ATMKDM4EALDH1A1
SCHEMBL12630123 0.77 ATM (0.54) GAPDHL3MBTL1ATMKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025093589-A1 HETEROARYL AMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS CHIESI FARMACEUTICI S.P.A. (IT) 2025-05-08 WO disclosed
CN-107252429-B Novel anti-inflammatory agent 雷斯韦洛吉克斯公司 2023-06-16 CN disclosed
EP-3431086-B1 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP (CA) 2020-06-17 EP disclosed
US-20200129512-A1 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP. (CA) 2020-04-30 US disclosed
EP-3431086-A1 NOVEL ANTI-INFLAMMATORY AGENTS Resverlogix Corp. (CA) 2019-01-23 EP disclosed
EP-2421533-B1 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP (CA) 2018-10-17 EP disclosed
US-20170333419-A1 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP. (CA) 2017-11-23 US disclosed
US-20170326143-A1 NOVEL ANTI-INFLAMMATORY AGENTS HEPALINK (HONG KONG) LIMITED (HK) 2017-11-16 US disclosed
US-9757368-B2 Anti-inflammatory agents RESVERLOGIX CORP. (CA) 2017-09-12 US disclosed
US-20130281398-A1 TREATMENT OF DISEASES BY EPIGENETIC REGULATION RVX THERAPEUTICS INC. (CA) 2013-10-24 US disclosed
WO-2008059239-A1 NOVEL COMPOUNDS 514 ASTRAZENECA AB (SE) 2008-05-22 WO disclosed
EP-1831208-A1 QUATERNARY AMMONIUM SALTS AS M3 ANTAGONISTS Novartis AG (CH) 2007-09-12 EP disclosed
EP-1831202-A1 PYRROLINIDIUM DERIVATIVES AS M3 MUSCARINIC RECEPTORS Novartis AG (CH) 2007-09-12 EP disclosed
EP-1811999-A1 QUINUCLIDINE DERIVATIVES AND THEIR USE AS MUSCARINIC M3 RECEPTOR ANTAGONISTS Novartis AG (CH) 2007-08-01 EP disclosed
US-20070060563-A1 Quinuclidine derivatives binding to mucarinic m3 receptors NOVARTIS AG (CH) 2007-03-15 US disclosed
WO-2006066929-A1 QUATERNARY AMMONIUM SALTS AS M3 ANTAGONISTS NOVARTIS AG (CH) 2006-06-29 WO disclosed
WO-2006066928-A1 PYRROLINIDIUM DERIVATIVES AS M3 MUSCARINIC RECEPTORS NOVARTIS AG (CH) 2006-06-29 WO disclosed
WO-2006048225-A1 QUINUCLIDINE DERIVATIVES AND THEIR USE AS MUSCARINIC M3 RECEPTOR ANTAGONISTS NOVARTIS AG (CH) 2006-05-11 WO disclosed
EP-1631569-A2 QUINUCLIDINE DERIVATIVES BINDING TO MUCARINIC M3 RECEPTORS Novartis AG (CH) 2006-03-08 EP disclosed
WO-2004096800-A2 QUINUCLIDINE DERIVATIVES BINDING TO MUCARINIC M3 RECEPTORS NOVARTIS AG (CH) 2004-11-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070060563-A1 Quinuclidine derivatives binding to mucarinic m3 receptors CHRM3, CHRM2, CHRM1 GAPDH 4028/4885L3MBTL1 3806/4885KMT2A 2755/4885
US-20130281398-A1 TREATMENT OF DISEASES BY EPIGENETIC REGULATION PHKB, BAZ2A, EP300 GAPDH 1949/4885L3MBTL1 659/4885KMT2A 199/4885
US-20170326143-A1 NOVEL ANTI-INFLAMMATORY AGENTS VCAM1, ICAM1, IL6 GAPDH 3703/4885L3MBTL1 4280/4885KMT2A 3505/4885
US-20170333419-A1 NOVEL ANTI-INFLAMMATORY AGENTS VCAM1, ICAM1, IL6 GAPDH 3703/4885L3MBTL1 4280/4885KMT2A 3505/4885
US-20200129512-A1 NOVEL ANTI-INFLAMMATORY AGENTS VCAM1, ICAM1, IL6 GAPDH 3703/4885L3MBTL1 4280/4885KMT2A 3505/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.