Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | GFER | P55789 | 1/20 | 0.70 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.56 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.53 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | CNR1 | P21554 | 2/20 | 0.48 |
| ▸ | CNR2 | P34972 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | YWHAG | P61981 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RGS12 | O14924 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17124778 | 0.91 | GAA (0.59) | GAAALDH1A1GFERHSP90AB1CYP4F2 | |
| SCHEMBL9202609 | 0.87 | ALDH1A1 (0.59) | GAAALDH1A1GFERHSP90AB1CYP4F2 | |
| SCHEMBL3668882 | 0.87 | GAA (0.72) | GAAALDH1A1GFERHSP90AB1CYP4F2 | |
| SCHEMBL29446278 | 0.87 | GAA (0.72) | GAAALDH1A1GFERHSP90AB1CYP4F2 | |
| SCHEMBL21076155 | 0.87 | ALDH1A1 (0.55) | GAAALDH1A1GFERHSP90AB1CYP4F2 | |
| SCHEMBL18269502 | 0.85 | ALDH1A1 (0.54) | GAAALDH1A1GFERHSP90AB1CYP4F2 | |
| Methyl Alcohol SCHEMBL27946196 | 0.85 | GAA (0.70) | GAAALDH1A1GFERHSP90AB1CYP4F2 | |
| SCHEMBL8145260 | 0.84 | ALDH1A1 (0.68) | GAAALDH1A1GFERHSP90AB1CYP4F2 | |
| SCHEMBL2127019 | 0.84 | GAA (0.68) | GAAALDH1A1GFERHSP90AB1CYP4F2 | |
| SCHEMBL30096935 | 0.84 | GAA (0.68) | GAAALDH1A1GFERHSP90AB1CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9499471-B2 | Biphenyl compounds for use in treating malaria and other parasitic disorders | MEDIZINISCHE HOCHSCHULE HANNOVER (DE) | 2016-11-22 | — | — | US | disclosed |
| US-9499471-B2 | Biphenyl compounds for use in treating malaria and other parasitic disorders | MEDIZINISCHE HOCHSCHULE HANNOVER (DE) | 2016-11-22 | — | — | US | disclosed |
| US-20150274637-A1 | BIPHENYL COMPOUNDS FOR USE IN TREATING MALARIA AND OTHER PARASITIC DISORDERS | GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER (DE) | 2015-10-01 | — | — | US | disclosed |
| US-20150274637-A1 | BIPHENYL COMPOUNDS FOR USE IN TREATING MALARIA AND OTHER PARASITIC DISORDERS | GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER (DE) | 2015-10-01 | — | — | US | disclosed |
| WO-2013034756-A1 | BIPHENYL COMPOUNDS FOR USE IN TREATING MALARIA AND OTHER PARASITIC DISORDERS | MEDIZINISCHE HOCHSCHULE HANNOVER (DE) | 2013-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274637-A1 | BIPHENYL COMPOUNDS FOR USE IN TREATING MALARIA AND OTHER PARASITIC DISORDERS | CYP1B1, CYP1A2, CYP1A1 | GAA 851/4885ALDH1A1 75/4885GFER 1256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.