Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLKL | Q8NB16 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.40 |
| ▸ | CYP2E1 | P05181 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CYP2C8 | P10632 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14770731 | 0.91 | MEN1 (0.49) | MLKLCYP1A2CYP2C19CYP2E1CYP3A4 | |
| SCHEMBL12066053 | 0.90 | MLKL (0.41) | MLKLCYP1A2CYP2C19CYP2E1CYP3A4 | |
| SCHEMBL12065643 | 0.90 | SCN10A (0.46) | MLKLCYP1A2CYP2C19CYP2E1CYP3A4 | |
| SCHEMBL14770686 | 0.87 | MLKL (0.60) | MLKLALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL14770549 | 0.86 | ALDH1A1 (0.42) | MLKLCYP1A2CYP2C19CYP2E1CYP3A4 | |
| SCHEMBL1460061 | 0.80 | KDM4E (0.58) | CYP1A2CYP2C19CYP2E1CYP3A4CYP2C8 | |
| SCHEMBL14770690 | 0.80 | MLKL (0.52) | MLKLCYP1A2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL5951828 | 0.77 | MEN1 (0.56) | CYP1A2CYP2C19CYP2E1CYP3A4CYP2C8 | |
| SCHEMBL5096626 | 0.77 | ALDH1A1 (0.47) | CYP1A2CYP2C19CYP2E1CYP3A4CYP2C8 | |
| SCHEMBL14762782 | 0.77 | SCN10A (0.43) | MLKLALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096531-B2 | Fused imidazole derivative | TOA EIYO LTD. (JP) | 2015-08-04 | — | — | US | disclosed |
| US-20130065896-A1 | FUSED IMIDAZOLE DERIVATIVE | TOA EIYO LTD. (JP) | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065896-A1 | FUSED IMIDAZOLE DERIVATIVE | CACNA1E, CACNA1G, CACNA1A | MLKL 2378/4885CYP1A2 2887/4885CYP2C19 1119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.