Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLKL | Q8NB16 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14770730 | 0.87 | MLKL (0.44) | MLKLSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL14770674 | 0.86 | SMN1; SMN2 (0.56) | MLKLSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL12065644 | 0.85 | MLKL (0.52) | MLKLSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL12066053 | 0.83 | MLKL (0.41) | MLKLSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL14770695 | 0.81 | CCNB2 (0.45) | MLKLSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL14770678 | 0.81 | MLKL (0.56) | MLKLSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL14770731 | 0.81 | MEN1 (0.49) | MLKLSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL14770661 | 0.80 | MLKL (0.72) | MLKLSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL17910926 | 0.79 | SMN1; SMN2 (0.51) | MLKLSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL12065643 | 0.77 | SCN10A (0.46) | MLKLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096531-B2 | Fused imidazole derivative | TOA EIYO LTD. (JP) | 2015-08-04 | — | — | US | disclosed |
| US-20130065896-A1 | FUSED IMIDAZOLE DERIVATIVE | TOA EIYO LTD. (JP) | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065896-A1 | FUSED IMIDAZOLE DERIVATIVE | CACNA1E, CACNA1G, CACNA1A | MLKL 2378/4885SMN1; SMN2 1964/4885NPC1 2440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.