Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 2/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.50 |
| ▸ | BBOX1 | O75936 | 9/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL3191898 | 0.89 | MEN1 (0.57) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL5574341 | 0.86 | FFAR3 (0.67) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL27491383 | 0.86 | MEN1 (0.62) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL6627654 | 0.86 | CYP3A4 (0.62) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Hexanoate SCHEMBL2762274 | 0.86 | CA1 (0.54) | BBOX1CA1CES2CES1 | |
| Glutarate SCHEMBL17982129 | 0.84 | MEN1 (0.52) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Stearic Acid SCHEMBL840883 | 0.84 | FABP3 (0.55) | BBOX1CA1CES2CES1 | |
| Octanoic Acid SCHEMBL2761867 | 0.84 | FABP3 (0.55) | BBOX1CA1CES2CES1 | |
| Myristic Acid SCHEMBL8588822 | 0.84 | FABP3 (0.55) | BBOX1CA1CES2CES1 | |
| Dodecanoate SCHEMBL19253062 | 0.84 | FABP3 (0.55) | BBOX1CA1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119913767-A | Method for extracting cellulose from biomass raw material | 中国石油化工股份有限公司 | 2025-05-02 | — | — | CN | claimed |
| CN-118058284-A | Fatty acid choline salt soluble solution and preparation method and application thereof | 郑州郑氏化工产品有限公司 | 2024-05-24 | — | — | CN | claimed |
| CN-116836098-B | Method for extracting and purifying astaxanthin from fermentation broth | 山东福瑞达生物科技有限公司 | 2024-05-07 | — | — | CN | claimed |
| CN-116836098-A | Method for extracting and purifying astaxanthin from fermentation broth | 山东福瑞达生物科技有限公司 | 2023-10-03 | — | — | CN | claimed |
| US-11642322-B2 | Food supplement and composition comprising choline butyrate salt and/or butyrylcholine | ABERGAVENNY NV (BE) | 2023-05-09 | — | — | US | claimed |
| EP-3448170-B1 | CHOLINE BUTYRATE SALT | ABERGAVENNY NV (BE) | 2022-03-16 | — | — | EP | claimed |
| US-11007159-B2 | Food supplement and composition comprising choline butyrate salt and/or butyrylcholine | ABERGAVENNY NV (BE) | 2021-05-18 | — | — | US | claimed |
| US-20190117594-A1 | FOOD SUPPLEMENT AND COMPOSITION COMPRISING CHOLINE BUTYRATE SALT AND/OR BUTYRYLCHOLINE | ABERGAVENNY NV (BE) | 2019-04-25 | — | — | US | claimed |
| CN-105061799-B | A kind of method that wheat stalk aeroge is prepared using choline butyrate | 河南科技大学 | 2018-05-11 | — | — | CN | claimed |
| WO-2017187335-A1 | FOOD SUPPLEMENT AND COMPOSITION COMPRISING CHOLINE BUTYRATE SALT AND/OR BUTYRYLCHOLINE | ABERGAVENNY NV (BE) | 2017-11-02 | — | — | WO | claimed |
| CN-105061799-A | Method for utilizing choline butyrate to prepare wheat straw aerogel | UNIV HENAN SCIENCE & TECH | 2015-11-18 | — | — | CN | claimed |
| EP-4748443-A2 | SOLID COMPOSITION SUITABLE AS A NUTRITIONAL COMPOSITION OR SUPPLEMENT FOR ANIMALS THAT SUFFER FROM BRAIN RELATED DISORDERS, DECLINE OR DISEASES | N.V. Nutricia (NL) | 2026-05-27 | — | — | EP | disclosed |
| EP-4401580-B1 | SOLID COMPOSITION SUITABLE AS A NUTRITIONAL COMPOSITION OR SUPPLEMENT FOR ANIMALS THAT SUFFER FROM BRAIN RELATED DISORDERS, DECLINE OR DISEASES | NUTRICIA NV (NL) | 2026-05-27 | — | — | EP | disclosed |
| CN-121574709-A | Biomass-based dust suppressant and preparation method and application thereof | 杭州格林微纳科技有限公司 | 2026-02-27 | — | — | CN | disclosed |
| EP-4493623-B1 | PET DEPOLYMERIZATION PROCESS | REPET S R L (IT) | 2026-01-21 | — | — | EP | disclosed |
| CN-105061799-A | Method for utilizing choline butyrate to prepare wheat straw aerogel | UNIV HENAN SCIENCE & TECH | 2015-11-18 | — | — | CN | disclosed |
| US-20120058057-A1 | Anti-dandruff Agents | MERCK PATENT GMBH (DE) | 2012-03-08 | — | — | US | disclosed |
| WO-2011061687-A2 | MULTIPLE-PHASE DIETARY SUPPLEMENT PRODUCT | UNIVERSITY OF THE FREE STATE (ZA) | 2011-05-26 | — | — | WO | disclosed |
| WO-2010136104-A2 | ANTI-DANDRUFF AGENTS | MERCK PATENT GMBH (DE) | 2010-12-02 | — | — | WO | disclosed |
| US-5342530-A | Using a cationic polyelectrolyte and salt mixture | NALCO CHEMICAL COMPANY (US) | 1994-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11642322-B2 | Food supplement and composition comprising choline butyrate salt and/or butyrylcholine | BCHE, CHAT, SLC10A2 | FFAR3 129/4885HDAC3 142/4885HDAC1 704/4885 |
| US-11007159-B2 | Food supplement and composition comprising choline butyrate salt and/or butyrylcholine | BCHE, CHAT, SLC10A2 | FFAR3 129/4885HDAC3 142/4885HDAC1 704/4885 |
| US-20190117594-A1 | FOOD SUPPLEMENT AND COMPOSITION COMPRISING CHOLINE BUTYRATE SALT AND/OR BUTYRYLCHOLINE | BCHE, CHAT, SLC10A2 | FFAR3 129/4885HDAC3 142/4885HDAC1 704/4885 |
| US-20120058057-A1 | Anti-dandruff Agents | POLR1C, ETF1, PIK3C3 | FFAR3 1689/4885HDAC3 171/4885HDAC1 226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.