Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 9/20 | 0.57 |
| ▸ | NPC1 | O15118 | 9/20 | 0.57 |
| ▸ | RAB9A | P51151 | 9/20 | 0.57 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.55 |
| ▸ | MMP14 | P50281 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | MMP9 | P14780 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2109899 | 0.84 | HSP90AA1 (0.56) | L3MBTL1ALOX12NPC1RAB9ANCOA3 | |
| SCHEMBL2110205 | 0.79 | TAS1R3 (0.58) | L3MBTL1ALOX12NPC1RAB9ANCOA3 | |
| SCHEMBL14776032 | 0.79 | TAS1R3 (0.58) | L3MBTL1ALOX12NPC1RAB9ANCOA3 | |
| SCHEMBL2111462 | 0.79 | L3MBTL1 (0.53) | L3MBTL1ALOX12NPC1RAB9ANCOA3 | |
| SCHEMBL2111795 | 0.78 | L3MBTL1 (0.55) | L3MBTL1ALOX12NPC1RAB9AHSP90AA1 | |
| SCHEMBL2111796 | 0.77 | NPC1 (0.54) | L3MBTL1ALOX12NPC1RAB9AHSP90AA1 | |
| SCHEMBL2111351 | 0.77 | NPC1 (0.54) | L3MBTL1ALOX12NPC1RAB9AKDM4E | |
| SCHEMBL2109821 | 0.77 | HSP90AA1 (0.49) | L3MBTL1ALOX12NPC1RAB9AHSP90AA1 | |
| SCHEMBL2109762 | 0.76 | ALDH1A1 (0.61) | L3MBTL1ALOX12NPC1RAB9AHSP90AA1 | |
| SCHEMBL2110248 | 0.76 | RIPK1 (0.52) | L3MBTL1ALOX12RAB9AHSP90AA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963272-B1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-03-20 | — | — | EP | claimed |
| EP-1963272-B1 | HYDROXYQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-03-20 | — | — | EP | disclosed |