Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 3/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.44 |
| ▸ | ME3 | Q16798 | 2/20 | 0.43 |
| ▸ | CASR | P41180 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | GRK2 | P25098 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10316360 | 0.89 | ITGB3 (0.52) | ITGB3ITGA2BNPC1RAB9AMCL1 | |
| SCHEMBL14780934 | 0.81 | USP2 (0.60) | NPC1RAB9AGPR119CASRMAPT | |
| SCHEMBL3486912 | 0.80 | GPR119 (0.73) | GPR119MAPT | |
| SCHEMBL11853729 | 0.79 | ITGB3 (0.57) | ITGB3ITGA2BNPC1RAB9AMCL1 | |
| SCHEMBL14780924 | 0.79 | GPR119 (0.63) | ITGB3ITGA2BNPC1RAB9AGPR119 | |
| SCHEMBL21624841 | 0.78 | USP2 (0.64) | ITGB3ITGA2BNPC1RAB9AMCL1 | |
| SCHEMBL13506075 | 0.78 | ITGB3 (0.47) | ITGB3ITGA2BNPC1RAB9AMCL1 | |
| SCHEMBL3485750 | 0.75 | GPR119 (0.47) | NPC1RAB9AMCL1GPR119ME3 | |
| SCHEMBL23583023 | 0.75 | ITGB3 (0.61) | ITGB3ITGA2BNPC1RAB9AMCL1 | |
| SCHEMBL20425020 | 0.75 | ITGB3 (0.54) | ITGB3ITGA2BNPC1RAB9AMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445499-B2 | Bipiperidinyl compounds, compositions, containing such compounds and methods of treatment | MERCK SHARP & DOHME CORP. (US) | 2013-05-21 | — | — | US | disclosed |
| US-8399485-B2 | Acyl bipiperidinyl compounds useful as GPR 119 agonists | MERCK SHARP & DOHME CORP. (US) | 2013-03-19 | — | — | US | disclosed |