Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.63 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.45 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.45 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.45 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.45 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14780934 | 0.88 | USP2 (0.60) | GPR119USP2L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL4555361 | 0.88 | GPR119 (0.66) | GPR119HRH3USP2L3MBTL1CHRNA7 | |
| SCHEMBL14780930 | 0.86 | GPR119 (0.47) | GPR119HRH3USP2L3MBTL1MBTD1 | |
| SCHEMBL14780920 | 0.79 | ITGB3 (0.50) | GPR119ITGB3ITGA2BNPC1MAPT | |
| SCHEMBL3486235 | 0.78 | GPR119 (1.00) | GPR119HRH3ALDH1A1LMNAMAPT | |
| SCHEMBL27712656 | 0.77 | NOTUM (0.54) | GPR119HRH3USP2CHRNA7CHRNA10 | |
| SCHEMBL2263367 | 0.77 | GPR119 (0.55) | GPR119HRH3USP2L3MBTL1CHRNA7 | |
| SCHEMBL11962881 | 0.77 | GPR119 (0.55) | GPR119HRH3USP2L3MBTL1CHRNA7 | |
| SCHEMBL18871943 | 0.77 | GPR119 (0.55) | GPR119HRH3USP2L3MBTL1CHRNA7 | |
| SCHEMBL13506522 | 0.76 | USP2 (0.64) | GPR119USP2L3MBTL1MBTD1TP53BP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399485-B2 | Acyl bipiperidinyl compounds useful as GPR 119 agonists | MERCK SHARP & DOHME CORP. (US) | 2013-03-19 | — | — | US | disclosed |