Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.47 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.47 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.47 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14780924 | 0.88 | GPR119 (0.63) | USP2GPR119L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL13506522 | 0.88 | USP2 (0.64) | USP2GPR119KDM4EL3MBTL1MBTD1 | |
| SCHEMBL14780930 | 0.82 | GPR119 (0.47) | USP2GPR119KDM4EL3MBTL1MBTD1 | |
| SCHEMBL14780920 | 0.81 | ITGB3 (0.50) | GPR119MAPTNPC1RAB9ACASR | |
| SCHEMBL2945397 | 0.78 | GPR119 (0.81) | USP2GPR119ALDH1A1MAPTLMNA | |
| SCHEMBL3458375 | 0.77 | USP2 (0.72) | USP2KDM4EL3MBTL1MBTD1TP53BP1 | |
| SCHEMBL1662934 | 0.77 | USP2 (0.72) | USP2KDM4EL3MBTL1MBTD1TP53BP1 | |
| SCHEMBL23610369 | 0.76 | KDM4E (0.71) | USP2KDM4EL3MBTL1ALDH1A1MAPT | |
| SCHEMBL17737082 | 0.76 | KDM4E (0.71) | USP2KDM4EL3MBTL1ALDH1A1MAPT | |
| SCHEMBL4555361 | 0.76 | GPR119 (0.66) | USP2GPR119L3MBTL1MBTD1TP53BP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445499-B2 | Bipiperidinyl compounds, compositions, containing such compounds and methods of treatment | MERCK SHARP & DOHME CORP. (US) | 2013-05-21 | — | — | US | disclosed |
| US-8399485-B2 | Acyl bipiperidinyl compounds useful as GPR 119 agonists | MERCK SHARP & DOHME CORP. (US) | 2013-03-19 | — | — | US | disclosed |