SCHEMBL1478095

SCHEMBL1478095

CCSC(=O)c1ccc(N([Si](C)(C)C)[Si](C)(C)C)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 9/20 0.40
HDAC4 P56524 9/20 0.40
HDAC1 Q13547 9/20 0.40
HDAC7 Q8WUI4 9/20 0.40
HDAC2 Q92769 9/20 0.40
HDAC10 Q969S8 9/20 0.40
HDAC11 Q96DB2 9/20 0.40
HDAC8 Q9BY41 9/20 0.40
HDAC6 Q9UBN7 9/20 0.40
HDAC9 Q9UKV0 9/20 0.40
HDAC5 Q9UQL6 9/20 0.40
KMT2A Q03164 3/20 0.37
L3MBTL1 Q9Y468 1/20 0.35
NOS1 P29475 3/20 0.34
MAPT P10636 3/20 0.33
ALDH1A1 P00352 2/20 0.33
HPGD P15428 2/20 0.33
TSHR P16473 1/20 0.33
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24703568 0.81 HDAC3 (0.44) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL1479121 0.81 KMT2A (0.40) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL1478659 0.79 HPGD (0.35) KMT2AMAPTALDH1A1HPGDNPC1
SCHEMBL1479313 0.78 HDAC6 (0.42) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3691267 0.75 HPGD (0.58) KMT2AMAPTALDH1A1HPGDNPC1
SCHEMBL3686294 0.74 MAPT (0.48) KMT2AL3MBTL1NOS1MAPTALDH1A1
SCHEMBL1583011 0.74 HPGD (0.54) KMT2AALDH1A1HPGDTSHRNPC1
SCHEMBL8468502 0.74 LMNA (0.52) KMT2ANOS1MAPTALDH1A1TSHR
SCHEMBL775487 0.74 HDAC1 (0.56) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL1478847 0.72 CA1 (0.58) KMT2AL3MBTL1MAPTALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8895670-B2 Functionalized polymers and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2014-11-25 US claimed
US-20110077325-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-03-31 US claimed
US-8895670-B2 Functionalized polymers and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2014-11-25 US disclosed
EP-2483317-B1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORP (JP) 2014-02-26 EP disclosed
EP-2483317-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE Bridgestone Corporation (JP) 2012-08-08 EP disclosed
US-20120184677-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2012-07-19 US disclosed
WO-2011041534-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-04-07 WO disclosed
US-20110077325-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-03-31 US disclosed