SCHEMBL1479313

SCHEMBL1479313

CCSC(=O)c1ccc(CN([Si](C)(C)C)[Si](C)(C)C)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 7/20 0.42
HDAC8 Q9BY41 6/20 0.42
HDAC1 Q13547 6/20 0.42
HDAC3 O15379 3/20 0.42
HDAC4 P56524 3/20 0.42
HDAC7 Q8WUI4 3/20 0.42
HDAC2 Q92769 3/20 0.42
HDAC10 Q969S8 3/20 0.42
HDAC11 Q96DB2 3/20 0.42
HDAC9 Q9UKV0 3/20 0.42
HDAC5 Q9UQL6 3/20 0.42
ALDH1A1 P00352 3/20 0.38
ALDH2 P05091 1/20 0.38
HRH3 Q9Y5N1 2/20 0.35
ACHE P22303 1/20 0.35
MEP1B Q16820 1/20 0.34
PYCR1 P32322 1/20 0.34
POLB P06746 1/20 0.34
MAPT P10636 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1478775 0.81 HDAC6 (0.36) HDAC6HDAC8HDAC1ALDH1A1ALDH2
SCHEMBL24703568 0.80 HDAC3 (0.44) HDAC6HDAC8HDAC1HDAC3HDAC4
SCHEMBL1478095 0.78 HDAC3 (0.40) HDAC6HDAC8HDAC1HDAC3HDAC4
SCHEMBL11897751 0.77 ALDH1A1 (0.55) ALDH1A1ALDH2MEP1BPOLBMAPT
SCHEMBL27261902 0.75 CA1 (0.52) HDAC6HDAC8HDAC1HDAC3HDAC4
SCHEMBL10301482 0.75 ALDH1A1 (0.39) HDAC6HDAC8HDAC1HDAC3HDAC4
SCHEMBL1479141 0.73 CA12 (0.56) ALDH1A1POLBMAPTSMN1; SMN2KMT2A
SCHEMBL8468502 0.72 LMNA (0.52) ALDH1A1HRH3ACHEPOLBMAPT
SCHEMBL775487 0.72 HDAC1 (0.56) HDAC6HDAC8HDAC1HDAC3HDAC4
SCHEMBL1478927 0.71 LOXL2 (0.40) HDAC6HDAC8HDAC1ALDH1A1ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8895670-B2 Functionalized polymers and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2014-11-25 US claimed
US-20110077325-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-03-31 US claimed
EP-2699606-B1 POLYMERS FUNCTIONALIZED WITH A CARBOXYLIC OR THIOCARBOXYLIC ESTER CONTAINING A SILYLATED AMINO GROUP BRIDGESTONE CORP (JP) 2016-09-28 EP disclosed
US-9403919-B2 Polymers functionalized with a carboxylic or thiocarboxylic ester containing a silylated amino group BRIDGESTONE CORPORATION (JP) 2016-08-02 US disclosed
US-8895670-B2 Functionalized polymers and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2014-11-25 US disclosed
EP-2483317-B1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORP (JP) 2014-02-26 EP disclosed
US-20140018500-A1 Polymers Functionalized With A Carboxylic Or Thiocarboxylic Ester Containing A Silylated Amino Group BRIDGESTONE CORPORATION (JP) 2014-01-16 US disclosed
US-20120184677-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2012-07-19 US disclosed
US-20110077325-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-03-31 US disclosed