SCHEMBL1479121

SCHEMBL1479121

CCSC(=O)c1cccc(N([Si](C)(C)C)[Si](C)(C)C)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.40
NOS3 P29474 2/20 0.37
NOS1 P29475 2/20 0.37
NOS2 P35228 2/20 0.37
KDM4E B2RXH2 2/20 0.36
ALDH1A1 P00352 2/20 0.36
MAPT P10636 2/20 0.36
HPGD P15428 2/20 0.36
ALOX15 P16050 1/20 0.36
HSD17B10 Q99714 1/20 0.36
HDAC3 O15379 6/20 0.35
HDAC4 P56524 6/20 0.35
HDAC1 Q13547 6/20 0.35
HDAC7 Q8WUI4 6/20 0.35
HDAC2 Q92769 6/20 0.35
HDAC10 Q969S8 6/20 0.35
HDAC11 Q96DB2 6/20 0.35
HDAC8 Q9BY41 6/20 0.35
HDAC6 Q9UBN7 6/20 0.35
HDAC9 Q9UKV0 6/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1478095 0.81 HDAC3 (0.40) KMT2ANOS3NOS1NOS2ALDH1A1
Ditophal SCHEMBL2109565 0.80 NOS3 (0.46) KMT2ANOS3NOS1NOS2ALDH1A1
SCHEMBL3688565 0.79 L3MBTL1 (0.47) KMT2AKDM4EALDH1A1MAPTHPGD
SCHEMBL1479227 0.78 TTR (0.47) KMT2AALDH1A1MAPTHPGDHSD17B10
SCHEMBL1583220 0.77 CA12 (0.47) KMT2AKDM4EALDH1A1MAPTHPGD
SCHEMBL3687994 0.77 ALDH1A1 (0.43) KMT2AKDM4EALDH1A1MAPTHPGD
SCHEMBL1478723 0.76 LMNA (0.50) KMT2AKDM4EALDH1A1MAPTHPGD
SCHEMBL3690725 0.74 L3MBTL1 (0.57) KMT2AKDM4EALDH1A1MAPTHPGD
SCHEMBL778106 0.74 HPGD (0.54) KMT2AKDM4EALDH1A1MAPTHPGD
SCHEMBL14114091 0.72 ALDH1A1 (0.54) KMT2ANOS3NOS1NOS2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8895670-B2 Functionalized polymers and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2014-11-25 US claimed
US-20110077325-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-03-31 US claimed
US-8895670-B2 Functionalized polymers and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2014-11-25 US disclosed
EP-2483317-B1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORP (JP) 2014-02-26 EP disclosed
EP-2483317-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE Bridgestone Corporation (JP) 2012-08-08 EP disclosed
US-20120184677-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2012-07-19 US disclosed
WO-2011041534-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-04-07 WO disclosed
US-20110077325-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-03-31 US disclosed