SCHEMBL1479085

SCHEMBL1479085

Fc1cc(Cl)c(Cl)cc1Br

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 10/20 0.50
KDM1B Q8NB78 6/20 0.50
AHR P35869 5/20 0.40
KCNH2 Q12809 4/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
MAPK1 P28482 1/20 0.32
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA9 Q16790 1/20 0.31
PLAU P00749 1/20 0.31
ELANE P08246 1/20 0.31
FLT1 P17948 1/20 0.30
ALDH1A1 P00352 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30826229 1.00 KDM1A (0.50) KDM1AKDM1BAHRKCNH2NPC1
SCHEMBL21218760 0.86 AHR (0.44) KDM1AKDM1BAHRKCNH2NPC1
SCHEMBL31070107 0.86 KDM1A (0.44) KDM1AKDM1BAHRKCNH2NPC1
SCHEMBL30892371 0.86 KDM1A (0.48) KDM1AKDM1BAHRKCNH2NPC1
SCHEMBL1397113 0.86 KDM1A (0.44) KDM1AKDM1BAHRKCNH2NPC1
SCHEMBL23539570 0.86 KDM1A (0.48) KDM1AKDM1BAHRKCNH2NPC1
SCHEMBL17543931 0.80 AHR (0.44) KDM1AKDM1BAHRCA1CA2
SCHEMBL3405663 0.79 TSHR (0.46) KDM1AKDM1BKCNH2NPC1RAB9A
SCHEMBL7160402 0.79 TSHR (0.46) KDM1AKDM1BKCNH2NPC1RAB9A
SCHEMBL17541224 0.79 GAA (0.50) KDM1AKDM1BAHRKCNH2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4610260-A1 ARYL HETEROCYCLIC KV1.3 INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF Shanghai Shenshi Wise Technology Co., Ltd. (CN) 2025-09-03 EP disclosed
CN-118693282-B Secondary battery and preparation method and application thereof 蜂巢能源科技股份有限公司 2024-12-03 CN disclosed
CN-118693282-A Secondary battery and preparation method and application thereof 蜂巢能源科技股份有限公司 2024-09-24 CN disclosed
WO-2024088343-A1 ARYL HETEROCYCLIC KV1.3 INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF 上海深势唯思科技有限责任公司 2024-05-02 WO disclosed
CN-117946111-A Aryl heterocycle Kv1.3 inhibitor and preparation method and application thereof 上海深势唯思科技有限责任公司 2024-04-30 CN disclosed
CN-106892803-A The preparation method of the fluorobenzaldehyde of 2,6 dichloro 3 and the preparation method of fluorine quinolone compounds 浙江朗华制药有限公司 2017-06-27 CN disclosed
EP-3150607-A1 MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF AbbVie Inc. (US) 2017-04-05 EP disclosed
EP-2560973-B1 MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF ABBVIE INC (US) 2016-11-16 EP disclosed
EP-2573074-B1 2-(2-fluoro-substituted phenyl)-6-amino-5-chloro-4- pyrimidinecarboxylates and their use as herbicides DOW AGROSCIENCES LLC (US) 2014-07-23 EP disclosed
US-8598085-B2 2-(2-fluoro-substituted phenyl)-6-amino-5-chloro-4-pyrimidinecarboxylates and their use as herbicides DOW AGROSCIENCES, LLC. (US) 2013-12-03 US disclosed
EP-2176239-B1 2-(2-FLUORO-SUBSTITUTED PHENYL)-6-AMINO-5-CHLORO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2012-12-19 EP disclosed
EP-2311815-B1 2-(2-Fluoro-substituted phenyl)-6-amino-5-chloro-4-pyrimidinecarboxylates and their use as herbicides DOW AGROSCIENCES LLC (US) 2012-12-19 EP disclosed
WO-2011133182-A1 MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF ABBOTT LABORATORIES (US) 2011-10-27 WO disclosed
US-20110130382-A1 MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF ABBOTT LABORATORIES (US) 2011-06-02 US disclosed
EP-2311815-A1 2-(2-Fluoro-substituted phenyl)-6-amino-5-chloro-4-pyrimidine carboxylates and their use as herbicides Dow AgroSciences LLC (US) 2011-04-20 EP disclosed
US-7915200-B2 2-(2-fluoro-substituted phenyl)-6-amino-5-chloro-4-pyrimidinecarboxylates and their use as herbicides DOW AGROSCIENCES LLC (US) 2011-03-29 US disclosed
US-20100120621-A1 2-(2-FLUORO-SUBSTITUTED PHENYL)-6-AMINO-5-CHLORO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2010-05-13 US disclosed
EP-2176239-A1 2-(2-FLUORO-SUBSTITUTED PHENYL)-6-AMINO-5-CHLORO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS HERBICIDES Dow AgroSciences LLC (US) 2010-04-21 EP disclosed
US-20090048109-A1 2-(2-FLUORO-SUBSTITUTED PHENYL)-6-AMINO-5-CHLORO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2009-02-19 US disclosed
WO-2009023438-A1 2-(2-FLUORO-SUBSTITUTED PHENYL)-6-AMINO-5-CHLORO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2009-02-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100120621-A1 2-(2-FLUORO-SUBSTITUTED PHENYL)-6-AMINO-5-CHLORO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS HERBICIDES DDT, DDC, PFAS KDM1A 1420/4885KDM1B 925/4885AHR 114/4885
US-20090048109-A1 2-(2-FLUORO-SUBSTITUTED PHENYL)-6-AMINO-5-CHLORO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS HERBICIDES DDT, DDC, PFAS KDM1A 1372/4885KDM1B 889/4885AHR 114/4885
US-20110130382-A1 MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF HTR4, HTR1A, HTR1D KDM1A 813/4885KDM1B 778/4885AHR 552/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.