SCHEMBL1479438

SCHEMBL1479438

CN(Cc1ccc(C(=S)O[Si](C)(C)C)cc1)[Si](C)(C)C

nearest known ligand 0.31

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.31
ALDH2 P05091 1/20 0.31
ACHE P22303 1/20 0.31
SMN1; SMN2 Q16637 2/20 0.30
PYCR1 P32322 1/20 0.30
POLB P06746 1/20 0.30
MAPT P10636 1/20 0.30
MGLL Q99685 1/20 0.30
CA12 O43570 1/20 0.30
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30
CA9 Q16790 1/20 0.30
HDAC3 O15379 1/20 0.30
HDAC4 P56524 1/20 0.30
HDAC1 Q13547 1/20 0.30
HDAC7 Q8WUI4 1/20 0.30
HDAC2 Q92769 1/20 0.30
HDAC10 Q969S8 1/20 0.30
HDAC11 Q96DB2 1/20 0.30
HDAC8 Q9BY41 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1478777 0.87 ALDH1A1 (0.33) ALDH1A1ALDH2SMN1; SMN2
SCHEMBL1478638 0.81 LOXL2 (0.38) ALDH1A1ACHESMN1; SMN2PYCR1POLB
SCHEMBL11897625 0.80 ALDH1A1 (0.37) ALDH1A1ALDH2ACHESMN1; SMN2PYCR1
SCHEMBL1478312 0.78 MAPT (0.31) ALDH1A1SMN1; SMN2MAPT
SCHEMBL1478660 0.73
SCHEMBL11897476 0.73 ALDH1A1 (0.52) ALDH1A1ALDH2SMN1; SMN2POLBMAPT
SCHEMBL1479314 0.69 ALDH1A1 (0.35) ALDH1A1ALDH2SMN1; SMN2POLBCA12
SCHEMBL1479787 0.67
SCHEMBL1478927 0.67 LOXL2 (0.40) ALDH1A1ACHESMN1; SMN2PYCR1POLB
SCHEMBL348507 0.67 ALDH1A1 (0.58) ALDH1A1SMN1; SMN2PYCR1MGLLCA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8895670-B2 Functionalized polymers and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2014-11-25 US claimed
US-20110077325-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-03-31 US claimed
EP-2699606-B1 POLYMERS FUNCTIONALIZED WITH A CARBOXYLIC OR THIOCARBOXYLIC ESTER CONTAINING A SILYLATED AMINO GROUP BRIDGESTONE CORP (JP) 2016-09-28 EP disclosed
US-9403919-B2 Polymers functionalized with a carboxylic or thiocarboxylic ester containing a silylated amino group BRIDGESTONE CORPORATION (JP) 2016-08-02 US disclosed
US-8895670-B2 Functionalized polymers and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2014-11-25 US disclosed
EP-2483317-B1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORP (JP) 2014-02-26 EP disclosed
US-20140018500-A1 Polymers Functionalized With A Carboxylic Or Thiocarboxylic Ester Containing A Silylated Amino Group BRIDGESTONE CORPORATION (JP) 2014-01-16 US disclosed
US-20120184677-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2012-07-19 US disclosed
US-20110077325-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-03-31 US disclosed