Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14795120 | 1.00 | ALOX5 (0.42) | ALOX5GRM2GRM3PDK1PDK2 | |
| SCHEMBL14795141 | 0.89 | THRA (0.42) | ALOX5HSD11B1THRATHRB | |
| SCHEMBL14795101 | 0.89 | THRA (0.42) | ALOX5HSD11B1THRATHRB | |
| SCHEMBL14795277 | 0.89 | THRA (0.42) | ALOX5HSD11B1THRATHRB | |
| SCHEMBL13580 | 0.83 | ALOX5 (0.42) | ALOX5GRM2GRM3EPHX1HPGD | |
| SCHEMBL8233826 | 0.82 | GRM2 (0.44) | ALOX5GRM2GRM3EPHX1HPGD | |
| SCHEMBL15525640 | 0.81 | HSD11B1 (0.42) | ALOX5GRM2GRM3EPHX1HPGD | |
| SCHEMBL28752678 | 0.81 | GRM2 (0.46) | ALOX5GRM2GRM3PDK1PDK2 | |
| SCHEMBL1711877 | 0.78 | GRM2 (0.43) | ALOX5GRM2GRM3PDK1PDK2 | |
| SCHEMBL1711870 | 0.78 | GRM2 (0.43) | ALOX5GRM2GRM3PDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571880-A1 | PYRROLO [2, 3 - B]PYRAZINE - 7 - CARBOXAMIDE DERIVATIVES AND THEIR USE AS JAK AND SYK INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-03-27 | — | — | EP | claimed |
| EP-2571880-A1 | PYRROLO [2, 3 - B]PYRAZINE - 7 - CARBOXAMIDE DERIVATIVES AND THEIR USE AS JAK AND SYK INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-03-27 | — | — | EP | disclosed |