Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13580 | 0.98 | ALOX5 (0.42) | HSD11B1ALOX5GRM2GRM3THRA | |
| SCHEMBL4185298 | 0.91 | HSD11B1 (0.47) | HSD11B1ALOX5GRM2GRM3THRA | |
| SCHEMBL31662066 | 0.83 | HSD11B1 (0.43) | HSD11B1ALOX5THRATHRBEPHX1 | |
| SCHEMBL31037391 | 0.82 | HSD11B1 (0.42) | HSD11B1ALOX5THRATHRB | |
| SCHEMBL14795154 | 0.81 | ALOX5 (0.42) | HSD11B1ALOX5GRM2GRM3THRA | |
| SCHEMBL14795120 | 0.81 | ALOX5 (0.42) | HSD11B1ALOX5GRM2GRM3THRA | |
| SCHEMBL3964139 | 0.80 | HSD11B1 (0.39) | HSD11B1THRATHRB | |
| SCHEMBL1682650 | 0.80 | GRM2 (0.43) | HSD11B1ALOX5GRM2GRM3THRA | |
| SCHEMBL8233826 | 0.79 | GRM2 (0.44) | ALOX5GRM2GRM3THRATHRB | |
| Hydrochloric Acid SCHEMBL29904537 | 0.79 | HSD11B1 (0.38) | HSD11B1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2852598-B3 | RING CONSTRAINED ANALOGS AS ARGINASE INHIBITORS | MARS INC (US) | 2016-10-19 | — | — | EP | disclosed |
| EP-2852598-B1 | RING CONSTRAINED ANALOGS AS ARGINASE INHIBITORS | MARS INC (US) | 2016-05-11 | — | — | EP | disclosed |
| US-9200011-B2 | Ring constrained analogs as arginase inhibitors | MARS, INCORPORATED (US) | 2015-12-01 | — | — | US | disclosed |
| EP-2852598-A1 | RING CONSTRAINED ANALOGS AS ARGINASE INHIBITORS | Mars, Incorporated (US) | 2015-04-01 | — | — | EP | disclosed |
| US-20150080341-A1 | RING CONSTRAINED ANALOGS AS ARGINASE INHIBITORS | MARS, INCORPORATED | 2015-03-19 | — | — | US | disclosed |
| WO-2013158262-A1 | RING CONSTRAINED ANALOGS AS ARGINASE INHIBITORS | MARS, INCORPORATED (US) | 2013-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150080341-A1 | RING CONSTRAINED ANALOGS AS ARGINASE INHIBITORS | ARG1, ARG2, PADI1 | HSD11B1 940/4885ALOX5 3799/4885GRM2 2719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.