Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.44 |
| ▸ | CDK1 | P06493 | 3/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.44 |
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14796414 | 0.91 | ALDH1A1 (0.51) | KDM4EMAPTRAB9APKMMCL1 | |
| SCHEMBL14796671 | 0.85 | ALDH1A1 (0.51) | KDM4EMAPTRAB9APKMMCL1 | |
| SCHEMBL14796427 | 0.81 | KDM4E (0.48) | KDM4EMAPTALDH1A1CCNB2CDK1 | |
| SCHEMBL14796696 | 0.81 | TOP1 (0.60) | KDM4EMAPTRAB9APKMNPSR1 | |
| SCHEMBL6203750 | 0.74 | ALDH1A1 (0.50) | KDM4EMAPTRAB9APKMMCL1 | |
| SCHEMBL6976263 | 0.73 | ALDH1A1 (0.78) | KDM4EMAPTRAB9AALDH1A1MEN1 | |
| SCHEMBL31188764 | 0.73 | ALDH1A1 (0.78) | KDM4EMAPTRAB9AALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL7234662 | 0.73 | ABCG2 (0.49) | KDM4EMAPTRAB9APKMMCL1 | |
| SCHEMBL6824577 | 0.71 | ALDH1A1 (0.47) | KDM4EMAPTRAB9AALDH1A1MEN1 | |
| SCHEMBL7669097 | 0.70 | ABCG2 (0.68) | KDM4EMAPTRAB9APKMMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9181193-B2 | Indenoquinolone compound, preparation method and use thereof | SECOND MILITARY MEDICAL UNIVERSITY, PLA (CN) | 2015-11-10 | — | — | US | disclosed |
| US-20130102598-A1 | INDENOQUINOLONE COMPOUND, PREPARATION METHOD AND USE THEREOF | SECOND MILITARY MEDICAL UNIVERSITY, PLA (CN) | 2013-04-25 | — | — | US | disclosed |
| EP-2573072-A1 | INDENOQUINOLONE COMPOUND, PREPARATION METHOD AND USE THEREOF | The Second Military Medical University, PLA (CN) | 2013-03-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130102598-A1 | INDENOQUINOLONE COMPOUND, PREPARATION METHOD AND USE THEREOF | TOP1, TOP2A, TOP2B | KDM4E 2199/4885MAPT 3771/4885RAB9A 3656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.