Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.95 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.95 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzo[D]Thiazole SCHEMBL3856663 | 1.00 | ALDH1A1 (0.95) | ALDH1A1HSD17B10NPC1RAB9ATDP1 | |
| Benzo[D]Thiazole SCHEMBL28208461 | 1.00 | ALDH1A1 (0.95) | ALDH1A1HSD17B10NPC1RAB9ATDP1 | |
| Benzo[D]Thiazole SCHEMBL8430 | 0.97 | — | — | |
| Benzo[D]Thiazole SCHEMBL10847268 | 0.97 | — | — | |
| Benzo[D]Thiazole SCHEMBL31388426 | 0.97 | — | — | |
| Benzo[D]Thiazole SCHEMBL451685 | 0.97 | — | — | |
| Benzo[D]Thiazole SCHEMBL900814 | 0.97 | ALDH1A1 (1.00) | ALDH1A1HSD17B10NPC1RAB9ATDP1 | |
| Benzo[D]Thiazole SCHEMBL28321476 | 0.95 | ALDH1A1 (0.86) | ALDH1A1HSD17B10NPC1RAB9ATDP1 | |
| Benzo[D]Thiazole SCHEMBL8822670 | 0.95 | ALDH1A1 (0.95) | ALDH1A1HSD17B10NPC1RAB9ATDP1 | |
| Benzo[D]Thiazole SCHEMBL3765441 | 0.95 | ALDH1A1 (0.95) | ALDH1A1HSD17B10NPC1RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10179774-B2 | Synthesis of chirally purified substituted benzothiazole diamines | KNOPP BIOSCIENCES LLC (US) | 2019-01-15 | — | — | US | disclosed |
| US-8519148-B2 | Reacting a solution comprising entantiomerically enriched 4,5,6,7-tetrahydro-benzothiazole diamine with an alkyl sulfonate or an alkyl halide in a solvent to form a reaction mixture and recovering a chirally purified substituted 4,5,6,7-tetrahydro-benzothiazole diamine; dopamine agonist | KNOPP NEUROSCIENCES, INC. (US) | 2013-08-27 | — | — | US | disclosed |
| US-20130079526-A1 | Synthesis of Chirally Purified Substituted Benzothiazole Diamines | KNOPP NEUROSCIENCES INC. (US) | 2013-03-28 | — | — | US | disclosed |
| CN-101715443-A | synthesis of chirally purified substituted benzothiazole diamines | KNOPP NEUROSCIENCES INC | 2010-05-26 | — | — | CN | disclosed |
| CN-101715443-A | synthesis of chirally purified substituted benzothiazole diamines | KNOPP NEUROSCIENCES INC | 2010-05-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10179774-B2 | Synthesis of chirally purified substituted benzothiazole diamines | SAT1, AADAT, DDC | ALDH1A1 213/4885HSD17B10 3152/4885NPC1 4771/4885 |
| US-20130079526-A1 | Synthesis of Chirally Purified Substituted Benzothiazole Diamines | SAT1, AADAT, DDC | ALDH1A1 213/4885HSD17B10 3152/4885NPC1 4771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.