Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 4/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14447679 | 0.85 | ALDH1A1 (0.45) | KDM4EMEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL5440644 | 0.80 | PRKDC (0.55) | KDM4EMEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL5801741 | 0.77 | KIF11 (0.44) | KDM4EMEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL5801743 | 0.72 | PRKDC (0.42) | KDM4EMEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL14802148 | 0.71 | PRKDC (0.41) | KDM4EMEN1KMT2AMAPTHPGD | |
| SCHEMBL30965983 | 0.69 | KIF11 (0.52) | KDM4EMEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL13429255 | 0.66 | ALDH1A1 (0.46) | KDM4EMEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL5459622 | 0.66 | PRKDC (0.45) | MAPTKIF11PRKDC | |
| SCHEMBL3729545 | 0.65 | APAF1 (0.61) | KDM4EMEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL5442834 | 0.64 | PRKDC (0.48) | KDM4EMEN1ALDH1A1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404681-B2 | Xanthones, thioxanthones and acridinones as DNA-PK inhibitors | LUITPOLD PHARMACEUTICALS, INC. (US) | 2013-03-26 | — | — | US | disclosed |