SCHEMBL1480432

SCHEMBL1480432

CC(C)(C)c1cc2c(cc1-c1ccc(-c3ccccc3)cc1)Cc1cc(-c3ccc(-c4ccccc4)cc3)c(C(C)(C)C)cc1-2

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TDP2 O95551 1/20 0.38
TYRO3 Q06418 1/20 0.36
NTRK2 Q16620 1/20 0.36
CLK4 Q9HAZ1 1/20 0.36
DYRK1B Q9Y463 1/20 0.36
KIF11 P52732 2/20 0.34
ESR1 P03372 1/20 0.33
ESR2 Q92731 1/20 0.33
BACE1 P56817 2/20 0.32
ADORA3 P0DMS8 1/20 0.32
ADORA2A P29274 1/20 0.32
ADORA1 P30542 1/20 0.32
RXRA P19793 1/20 0.32
RXRB P28702 1/20 0.32
MAPT P10636 1/20 0.32
TRPA1 O75762 1/20 0.31
PARP10 Q53GL7 1/20 0.31
PARP11 Q9NR21 1/20 0.31
PDK2 Q15119 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL312383 0.96 BACE1 (0.34) TDP2ESR1ESR2BACE1ADORA3
SCHEMBL1481324 0.91 NPC1 (0.37) TDP2KIF11BACE1RXRARXRB
SCHEMBL312040 0.84 KIF11 (0.41) TDP2KIF11MAPT
SCHEMBL4954208 0.84 ESR1 (0.36) ESR1ESR2MAPT
SCHEMBL1479983 0.83 TDP2 (0.37) TDP2NTRK2ESR1ESR2MAPT
SCHEMBL1480584 0.83 PTGS2 (0.38) ESR1ESR2MAPT
SCHEMBL4952869 0.82 GSTP1 (0.43) ESR1ESR2BACE1MAPTTRPA1
SCHEMBL1479601 0.81 TDP2 (0.43) TDP2KIF11ESR1ESR2BACE1
SCHEMBL1482711 0.80 ABL1 (0.41) BACE1ADORA1MAPT
SCHEMBL15949936 0.79

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8293856-B2 Process for preparing olefin polymer using mixed catalyst MITSUI CHEMICALS, INC. (JP) 2012-10-23 US disclosed
US-20110077369-A1 PROCESS FOR PREPARING OLEFIN POLYMER USING MIXED CATALYST MITSU CHEMICALS, INC. 2011-03-31 US disclosed