Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBE2M | P61081 | 3/20 | 0.48 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | CCR4 | P51679 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14815334 | 0.94 | KCNH2 (0.43) | UBE2MDCUN1D1KCNH2CACNA1ILMNA | |
| SCHEMBL14815382 | 0.94 | SIGMAR1 (0.46) | PPARGKCNH2CACNA1ILMNAHTR1A | |
| SCHEMBL14815277 | 0.90 | UBE2M (0.48) | UBE2MDCUN1D1LMNAHTR1AHTR7 | |
| SCHEMBL14815237 | 0.80 | DRD2 (0.43) | HTR1AHTR7KDM4EALDH1A1MAPT | |
| SCHEMBL14815148 | 0.77 | DRD2 (0.48) | HTR1AHTR7KDM4EALDH1A1MEN1 | |
| SCHEMBL14815064 | 0.77 | HRH1 (0.45) | ALDH1A1MEN1KMT2ANPSR1CACNA1B | |
| SCHEMBL14833401 | 0.75 | UBE2M (0.46) | UBE2MDCUN1D1PPARGLMNAHTR1A | |
| SCHEMBL14815089 | 0.75 | UBE2M (0.46) | UBE2MDCUN1D1PPARGLMNAHTR1A | |
| SCHEMBL14815352 | 0.74 | CA1 (0.45) | LMNAHTR1AHTR7MEN1KMT2A | |
| SCHEMBL14815248 | 0.74 | CACNA1B (0.49) | UBE2MDCUN1D1ALDH1A1HTTCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130085142-A1 | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS | ABBVIE INC. (US) | 2013-04-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130085142-A1 | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS | CACNA1C, CACNA1E, CACNA1D | UBE2M 4772/4885DCUN1D1 1024/4885PPARG 3460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.