Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBE2M | P61081 | 1/20 | 0.46 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | LIPE | Q05469 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | CCR2 | P41597 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14815089 | 1.00 | UBE2M (0.46) | UBE2MDCUN1D1PPARGLIPEALDH1A1 | |
| SCHEMBL14815110 | 0.94 | DRD2 (0.42) | PPARGLIPEDRD2ADRA1DADRA1A | |
| SCHEMBL14833228 | 0.94 | DRD2 (0.42) | PPARGLIPEDRD2ADRA1DADRA1A | |
| SCHEMBL14815157 | 0.94 | DRD2 (0.45) | PPARGALDH1A1KDM4EDRD2ADRA1D | |
| SCHEMBL14833227 | 0.94 | DRD2 (0.45) | PPARGALDH1A1KDM4EDRD2ADRA1D | |
| SCHEMBL14815095 | 0.90 | CCR2 (0.48) | UBE2MDCUN1D1DRD2ADRA1DADRA1A | |
| SCHEMBL14833369 | 0.90 | CCR2 (0.48) | UBE2MDCUN1D1DRD2ADRA1DADRA1A | |
| SCHEMBL14833215 | 0.80 | DRD2 (0.47) | ALDH1A1KDM4EDRD2ADRA1DADRA1A | |
| SCHEMBL14815077 | 0.80 | DRD2 (0.47) | ALDH1A1KDM4EDRD2ADRA1DADRA1A | |
| SCHEMBL14815367 | 0.77 | DRD2 (0.46) | ALDH1A1DRD2ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013049164-A1 | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS | ABBVIE INC. (US) | 2013-04-04 | — | — | WO | claimed |
| WO-2013049164-A1 | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS | ABBVIE INC. (US) | 2013-04-04 | — | — | WO | disclosed |