Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14819909 | 0.90 | PPARD (0.40) | GFERRAB9AMAPTNPC1GAA | |
| SCHEMBL2004352 | 0.83 | DCTPP1 (0.38) | TDP1MAPTFOXO1ALDH1A1POLB | |
| SCHEMBL2003157 | 0.79 | MAOA (0.44) | TDP1TTRALDH1A1 | |
| SCHEMBL2006768 | 0.77 | PTGDR (0.53) | — | |
| SCHEMBL2001572 | 0.77 | ALDH1A1 (0.39) | GFERFOXO1GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL13816310 | 0.76 | ALDH1A1 (0.48) | TDP1RAB9AMAPTNPC1GAA | |
| SCHEMBL2008340 | 0.75 | DCTPP1 (0.35) | TDP1MAPTGAASMN1; SMN2HPGD | |
| SCHEMBL4992802 | 0.74 | ALDH1A1 (0.52) | GFERTDP1MAPTGAAHPGD | |
| SCHEMBL2004566 | 0.73 | CYP3A4 (0.39) | MAPTHPGDALDH1A1 | |
| SCHEMBL7475985 | 0.72 | GAA (0.49) | GFERTDP1RAB9AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164828-B1 | COMPOUNDS AS CRTH2 AND/OR PGD2 RECEPTORS MODULATORS AND THEIR USE FOR TREATING ASTHMA AND ALLERGIC INFLAMMATION | AMGEN INC (US) | 2013-03-27 | — | — | EP | disclosed |