Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | RHEB | Q15382 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14819904 | 0.90 | GFER (0.39) | GFERGAANPC1MAPTRAB9A | |
| SCHEMBL2004566 | 0.82 | CYP3A4 (0.39) | PPARDPPARAPPARGPTGDR2PTGDR | |
| SCHEMBL2003571 | 0.78 | PPARD (0.40) | PPARDPPARAPPARGPTGDR2PTGDR | |
| SCHEMBL2006729 | 0.76 | PDE7A (0.47) | PPARDPPARAPTGDR2PTGDRFFAR1 | |
| SCHEMBL2003584 | 0.75 | PTGDR (0.62) | PTGDR2PTGDR | |
| SCHEMBL14819947 | 0.75 | PPARD (0.38) | PPARDPPARAPPARGPTGDR2PTGDR | |
| SCHEMBL3641599 | 0.74 | PPARD (0.39) | PPARDPPARAPPARGPTGDR2PTGDR | |
| SCHEMBL2003153 | 0.74 | PPARD (0.39) | PPARDPPARAPPARGPTGDR2PTGDR | |
| SCHEMBL2004352 | 0.72 | DCTPP1 (0.38) | MAPTPOLB | |
| SCHEMBL8909197 | 0.72 | ALDH1A1 (0.54) | PPARGPRKAG1PRKAA2PRKAB1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164828-B1 | COMPOUNDS AS CRTH2 AND/OR PGD2 RECEPTORS MODULATORS AND THEIR USE FOR TREATING ASTHMA AND ALLERGIC INFLAMMATION | AMGEN INC (US) | 2013-03-27 | — | — | EP | disclosed |