Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | DCTPP1 | Q9H773 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3641599 | 0.90 | PPARD (0.39) | PPARDPPARAPPARGDCTPP1ALDH1A1 | |
| SCHEMBL2003153 | 0.90 | PPARD (0.39) | PPARDPPARAPPARGDCTPP1ALDH1A1 | |
| SCHEMBL2008340 | 0.82 | DCTPP1 (0.35) | PPARDPPARAPPARGDCTPP1ALDH1A1 | |
| SCHEMBL14819929 | 0.79 | ALDH1A1 (0.34) | PPARGDCTPP1ALDH1A1MEN1KMT2A | |
| SCHEMBL14819909 | 0.75 | PPARD (0.40) | PPARDPPARAPPARGPTGDRPTGDR2 | |
| SCHEMBL2002775 | 0.69 | DCTPP1 (0.35) | PPARGDCTPP1ALDH1A1MEN1KMT2A | |
| SCHEMBL12570878 | 0.68 | DCTPP1 (0.34) | PPARGDCTPP1ALDH1A1MEN1KMT2A | |
| SCHEMBL2006729 | 0.68 | PDE7A (0.47) | PPARDPPARAALDH1A1PTGDRPTGDR2 | |
| SCHEMBL14819904 | 0.67 | GFER (0.39) | ALDH1A1TTRNPC1HTTRAB9A | |
| SCHEMBL2003571 | 0.65 | PPARD (0.40) | PPARDPPARAPPARGALDH1A1PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164828-B1 | COMPOUNDS AS CRTH2 AND/OR PGD2 RECEPTORS MODULATORS AND THEIR USE FOR TREATING ASTHMA AND ALLERGIC INFLAMMATION | AMGEN INC (US) | 2013-03-27 | — | — | EP | disclosed |