Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | AR | P10275 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23717308 | 0.87 | ALDH1A1 (0.77) | ALDH1A1HPGDHSD17B10CYP1A2CYP2C9 | |
| SCHEMBL9674830 | 0.84 | ALDH1A1 (0.58) | ALDH1A1HPGDHSD17B10CYP1A2CYP2C9 | |
| SCHEMBL171627 | 0.78 | KDM4E (0.60) | ALDH1A1HPGDHSD17B10CYP1A2CYP2C9 | |
| SCHEMBL5681855 | 0.76 | NPSR1 (0.59) | ALDH1A1HPGDHSD17B10CYP1A2CYP2C9 | |
| SCHEMBL8502483 | 0.76 | MAPT (0.45) | ALDH1A1HPGDHSD17B10MAPTKDM4E | |
| SCHEMBL13483956 | 0.75 | NPSR1 (0.54) | ALDH1A1HPGDHSD17B10CYP1A2CYP2C9 | |
| SCHEMBL11546301 | 0.75 | TYMS (0.52) | ALDH1A1HPGDHSD17B10MAPTKDM4E | |
| SCHEMBL12892268 | 0.75 | ALDH1A1 (0.40) | ALDH1A1HPGDHSD17B10MAPTKDM4E | |
| SCHEMBL8502457 | 0.75 | ALDH1A1 (0.40) | ALDH1A1HPGDHSD17B10NPSR1MAPT | |
| SCHEMBL8502481 | 0.75 | ALDH1A1 (0.40) | ALDH1A1HPGDHSD17B10MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130079323-A1 | GYRASE INHIBITORS | TRIUS THERAPEUTICS, INC. (US) | 2013-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130079323-A1 | GYRASE INHIBITORS | TOP1, CA7, TOP2B | ALDH1A1 2837/4885HPGD 1233/4885HSD17B10 200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.